摘要
目的评价MicroPure成像技术检测乳腺肿瘤微钙化及鉴别乳腺良恶性肿瘤的价值。方法对经钼靶X线检查证实存在微钙化灶的110例乳腺肿瘤患者(125个肿瘤)进行常规高频超声及配有MicroPure成像技术的超声检查,记录微钙化灶检出率,对乳腺肿瘤进行BI-RADS分级。以术后病理结果为金标准,比较常规高频超声及MicroPure成像技术诊断乳腺恶性肿瘤的准确率;绘制ROC曲线,比较两种方法诊断乳腺恶性肿瘤的能力。结果 MicroPure成像技术对于微钙化的检出率(125/125,100%)高于常规高频超声(97/125,77.60%,χ2=29.32,P<0.05)。对低回声病灶的微钙化,MicroPure成像技术的检出率(69/69,100%)与常规高频超声(67/69,97.10%)差异无统计学意义(χ2=0.507,P>0.05);而对非低回声病灶的微钙化,MicroPure成像技术的检出率(56/56,100%)明显高于常规高频超声(30/56, 53.57%,χ2=31.31,P<0.05)。MicroPure成像技术诊断乳腺恶性肿瘤的特异度、敏感度及准确率分别为86.21%(50/58)、95.52%(64/67)、91.20%(114/125),常规高频超声则分别为86.21%(50/58)、74.63%(50/67)和80.00%(100/125),二者诊断敏感度和准确率差异有统计学意义(P均<0.05)。MicroPure成像技术诊断乳腺恶性肿瘤ROC曲线下面积(0.944)大于常规高频超声(0.859)。结论 MicroPure成像技术可提高乳腺病灶微钙化的检出率,进而提高诊断乳腺恶性肿瘤的敏感度和准确率。
Objective To observe the value of MieroPure imaging on detection of microcalcifications and in differential di- agnosis of benign and malignant breast cancer. Methods Totally 110 patients with 125 breast neoplasms having microcalci- fications confirmed by molybdenum target X-ray mammography underwent high-frequency ultrasound and MicroPure ima- ging. The detection rate of microcalcification was calculated, and the BI-RADS classification was performed. Taking patho- logical result as gold standards, the diagnostic accuracy for breast cancer was compared between MicroPure imaging and high-frequency ultrasound. ROC curve was drawn to analyze the diagnostic efficiency of these two methods. Results The detection rate of microcalcification of MicroPure imaging was 100% （125/125）, significantly higher than that in high-fre- quency ultrasound （97/125, 77.60 % ; χ2 = 29.32, P〈0.05）. For hypoechoic tumors, the detection rate for microcalcifica- tion was not significantly different between MicroPure imaging （69/69, 100%） and high-frequency ultrasound （67/69, 97.10 % ; χ2 = 0. 507, P〉0.05）, while for non-hypoeehoic tumors, the detection rate for microcaleifieation of MicroPure imaging （56/56, 100%） was higher than that in high-frequency ultrasound （30/56, 53.57% ;χ2 =31： 31, P%0.05）. The specificity, sensitivity and accuracy of MicroPure imaging for diagnosing breast cancer was 86.21% （50/58）, 95.52 % （64/ 67） and 91.20%（114/125）,while of high-frequency ultrasound was 86.21% （50/58）, 74.63% （50/67）and 80.00%（100/ 125）, respectively, with statistical difference in sensitivity and accuracy （both P〈0.05）. The area under ROC curve of MicroPure imaging （0. 944） was bigger than high-frequency uItrasonography （0. 859） for diagnosing breast cancer. Conclu- sion The detection rate for microcalcifications can be increased using MicroPure imaging, therefore improving the diagnos- tic sensitivity and accuracy of breast cancer.
出处
《中国介入影像与治疗学》
CSCD
2013年第10期599-602,共4页
Chinese Journal of Interventional Imaging and Therapy
基金
蚌埠市科技基金项目([2012]58-0403)
