摘要
目的 本文探讨微生态调节剂枯草杆菌二联活菌肠溶胶囊对肝硬化患者肠道菌群、血清内毒素以及肝功能的影响.方法 将肝硬化患者82例随机分为对照组41例和治疗组41例,两组均给予保肝、利尿和营养支持等常规治疗,对照组给予口服复方甘草酸苷；治疗组加用枯草杆菌二联活菌制剂.观察治疗前后两组患者肠道菌群菌落计数的变化,并对血清天门冬氨酸转移酶（AST）及丙氨酸氨基转移酶（ALT）及内毒素的变化进行比较分析.结果 治疗前两组患者肠道菌群、肝功能（ALT、AST）和内毒素无明显差异（P＞0.05）.治疗3周后,治疗组肠道有益菌群明显增加,较治疗前有显著差异（P＜0.05）；血清内毒素和ALT、AST水平均较治疗前明显下降（P＜0.05）.结论 枯草杆菌二联活菌制剂可使肝硬化患者肠道的正常菌群恢复平衡、降低血清内毒素水平、对肝硬化患者肝功能的恢复有一定辅助作用,安全有效.
Objective To explore the effect of live combined Bacillus subtilis and Enterococcus faecium on gut barrier and endotoxin of hepatic cirrhosis patients. Methods 82 hepatic cirrhosis patients were divided into two groups. The control group patients were given regular liver treatment and compound glycyrrhisim. And treatment group were given live combined Bacillus subtilis and Enterococcus faecium. The change of intestinal bacterial colony count, endotoxin and liver function in the two groups of patients were observed after the treatment. Results Intestinal flora, liver function （ALT, AST） and endotoxin has no obvious difference of two groups before treatment（P〉0.05）. 3 weeks later, beneficial bacteria of treatment group in the intestine increased significantly, there were significant differences compared with treatment, before（P〈0.05）; serum levels of endotoxin and ALT, AST decreased Significantly（P〈0.05）. Conclusion Live combined bacillus subtilis and enterococcus faecium can make the normal flora of intestinal tract in patients with cirrhosis, improve the serum endotoxin, and it have auxiliary function on the recovery of liver function in patients with cirrhosis of the liver, could be helpful for hepatic cirrhosis treatment.
关键词
肝硬化
枯草杆菌二联活菌
复方甘草酸苷
肠道菌群
Cirrhosis
Live combined Bacillus subtilis and Enterococcus faecium
Compound glycyrrhisim
Intestinal bacterial colony
