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氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病30例疗效观察 被引量：4

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摘要 目的探讨氟达拉滨联合环磷酰胺(FC)方案治疗慢性淋巴细胞白血病(CLL)的疗效以及不良反应。方法回顾分析30例经FC方案治疗的CLL患者的临床资料,评估患者临床分期及疗效,同时观察患者对药物的不良反应。结果 30例患者中,10例(33.33%)获得完全缓解(CR),8例(26.67%)为部分缓解(PR),总缓解率为60.00%;Binet A+B期总缓解率(80.00%)明显高于C期总缓解率(20.00%),治疗反应差异有统计学意义(P<0.05);治疗过程中出现的不良反应主要为不同程度的骨髓抑制、胃肠道反应和感染。结论氟达拉滨联合环磷酰胺用药安全性好,有效率高,大大提高了CLL的治疗效果。
作者 梁兴林 吴炜 夏瑞祥
机构地区 安徽医科大学第一附属医院血液科
出处 《安徽医学》 2013年第9期1354-1355,共2页 Anhui Medical Journal
关键词 白血病 淋巴细胞 氟达拉滨 环磷酰胺
分类号 R733.72 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献19

同被引文献37

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  • 5Pepper C, Lowe H, Fegan C, et al. Fludarabine - media- ted suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinkingagent SJG - 136( NSC 694501 ) in chronic lymphocyticleukaemia cells [ J ]. Br J Cancer, 2007,97 (2) :253 -259.
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引证文献4

二级引证文献16

安徽医学
2013年 第9期

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