摘要
目的:探讨雌激素受体( ER)α基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的关系。方法:将2002年至2012年国内外发表的ERα基因PvuⅡrs2234693多态性与乳癌关系相关的文献进行检索,并进行异质性检验,计算OR值(95%CI)。结果:符合纳入标准的共有14篇文献,累计乳癌病例10755例,对照17074例。与野生纯合基因型TT相比,CC突变基因型异质性检验P=0.03,OR(95%CI)为0.91(0.81~1.02);CT杂合型及CC+CT联合型的异质性检验P分别为0.57、0.44,OR(95%CI)分别为0.96(0.90~1.02)、0.94(0.89~1.00)。结论:未发现ERα基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的相关性。
Aim:To explore the relationship between PvuⅡrs2234693 polymorphisms in estrogen receptor α( ERα) and risk of breast cancer occurrence .Methods: All literatures related to PvuⅡrs2234693 polymorphisms in ERαand breast cancer which published openly between 2002 and 2012 were reviewed .Heterogeneity test for each research data was performed and OR(95%CI) was analyzed.Results:There were 14 literatures conformed to the inclusion criteria .A total of 10 755 breast cancer cases and 17 074 controls were included .The meta-analysis showed that compared with the wild-type homozygous TT, the P of heterogeneity test for CC variant genotype was 0.03, and OR(95%CI) was 0.91(0.81-1.02).The P of heterogeneity test for CT heterozygous and CC +CT joint type was 0.57, 0.44, and OR(95%CI) was 0.96(0.90-1.02), 0.94(0.89-1.00).Conclusion: No relationship between the genotype of PvuⅡrs2234693 poly-morphisms in ERαand risk of breast cancer occurrence is found .
出处
《郑州大学学报(医学版)》
CAS
北大核心
2013年第5期588-591,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金资助项目81202278
关键词
雌激素受体Α
多态性
乳癌
META分析
estrogen receptor α
polymorphism
breast cancer
meta-analysis