摘要
目的:评价中药安君宁治疗海洛因依赖稽延性戒断症状(PWS)的疗效及安全性。方法:纳入符合诊断标准的海洛因依赖患者,随机分为安君宁治疗组和安慰剂对照组。采用随机双盲临床研究方法,进行6个月的随访治疗比较,观察指标为稽延性戒断症状评定量表(PWS)、汉密尔顿焦虑量表(HAMA)等。结果:PWS量表提示与安慰剂比较,安君宁在访视3(第4周),稽延性戒断症状量表睡眠因子分差异存在统计学意义(p<0.05)。汉密尔顿焦虑量表提示与安慰剂比较,安君宁在访视前后,汉密尔顿焦虑评分差异不存在统计学意义(P>0.05)。结论:在治疗海洛因依赖稽延性戒断症状时,中药安君宁可以有效缓解巩固期睡眠障碍。
Objective： To evaluate the curative effect of adverse reaction of Anjunning in treatment of protracted withdrawal symp- toms（PWS） of herion dependence. Methods： The herion addicts meeting ICD-10 were randomized to Anjunning group and placebo group with double blinding. It was 6 months in treatment. The Scale of PWS and HAMA were used to assess the curative effect. Results ： Comparing that of placebo group, sleep disorder score of PWS score of Anjunning group was remarkable different during the 3^rd interviews （p 〈 0. 05）. HAMA score of Anjunning group was not different with that of placebo group during the interviews. Conclusion： Anjunning is firstly effective in treatment of sleep disorder of PWS.
出处
《中国药物滥用防治杂志》
CAS
2013年第5期251-255,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
国家科技部十一五支撑计划课题资助项目
课题编号:2008BAI49B02
关键词
安君宁
稽延性戒断症状
Anjunning
PWS（protracted withdrawal symptoms）
