摘要
目的：探讨不同服药时间对老年高血压患者血压节律性的影响。方法：将120例老年高血压患者随机分为2组，治疗组晨服非洛地平缓释片，晚服马来酸依那普利；对照组晨服非洛地平缓释片＋马来酸依那普利。分别于服药前和服药后8周监测其动态血压，比较其血压节律性的变化。结果：服药8周后，治疗组和对照组患者的血压均较治疗前明显下降（P〈0．01）；治疗组患者的白天舒张压、夜间血压、24h收缩压及晨间血压下降幅度均优于对照组（P〈0．05～P〈0．01）；并且，2组患者治疗前非杓型患者的比例分别为89．2％和89．1％，治疗后分别为50．8％和72．7％，治疗组昼夜节律的改善率优于对照组（P〈0．05）。结论：结合不同降压药，分不同时间服药能明显纠正患者夜间血压，显著改善血压的节律性，抑制晨峰现象的出现，更好地保护靶器官。
Objective：To explore the effects of taking medicine in different time on the rhythm of blood pressure of elderly patients with hypertension. Methods：One hundred and twenty elderly patients with hypertension were randomly divided into treatment group and control group. The treatment group were treated with felodipine in the morning and enalapril in the evening by oral, the control group were treated with felodipine and enalapril in the morning by oral. The ambulatory blood pressure in two groups were monitored before treatment and after taking medicine 8 weeks, the rhythm of blood pressure of which was compared. Results：The blood pressure of both groups before eatment and after taking medicineat 8 weeks were obviously lower than that in taking medicines（ P 〈 0.01 ）, the falling range of diastolic pressure at day, blood pressure at night, 24 h SBP and blood pressure in the morning of the treatment group were better than those in control group（ P 〈 0.05 to P 〈 0.01 ）. The proportion of non dipper type patients in two groups before treatment were 89.2% and 89.1% ,and 50.8% and 72.7% after treatment, respectively. The improvement of rhythm of blood pressure in treatment group was significantly better than that in control group （ P 〈 0.05 ）. Conclusions： The different taking medicine styles can significant improve the rhythm of blood pressure and protect target organ of elderly patients with hypertension.
出处
《蚌埠医学院学报》
CAS
2013年第10期1296-1298,共3页
Journal of Bengbu Medical College
关键词
高血压
服药时间
血压节律性
老年医学
hypertension
taking medication time
rhythm of blood pressure
geriatrics
