摘要
线粒体是细胞供能代谢中心,同时也是众多环境化学外源物毒害作用的优先靶标。线粒体损伤包括形态结构破坏、线粒体DNA突变、ATP合成受限、钙稳态失衡、氧化应激产物积聚及代谢功能障碍。线粒体呼吸链已经被广泛证实是活性氧产生的最主要来源,过多产生的超氧化物若未被内源性抗氧化剂或相关酶清除,便会导致线粒体的氧化应激损伤和功能障碍,从而引发细胞死亡等多种病变。
Mitochondria are the center of energy metabolism in cells and the preferential targets affected by various environmental toxicants. Mitochondrial injury is concerned with morphological destruction, mitochondrial DNA mutations, restriction of ATP synthesis, imbalance of calcium steady-state, accumulation of oxidative stress products and metabolic dysfunction. Mitochondrial respiratory chain is widely proved to be the most important source of oxygen free radicals. If the overproduced superoxides are not eliminated by the endogenous antioxidants or related enzymes, they will cause mitochondrial oxidative stress injury and dysfunction, leading to cell death and other lesions. This paper will reviewe the correlation between the mitochondrial injury and oxidative stress.
出处
《国外医学（医学地理分册）》
CAS
2013年第3期197-201,共5页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学基金资助项目(No.81160335)
国际科技合作项目(No.2010DFB30530)
科技部支撑计划课题(No.2011BAZ03220)
贵州省科技厅项目[No.黔科合外G字(2011)7014号]
关键词
线粒体
损伤
氧化应激
mitochondria
injury
oxidative stress
