摘要
目的观察依那普利联合美托洛尔治疗慢性心力衰竭的临床效果。方法将124例慢性心力衰竭患者随机分为观察组和对照组各62例。对照组接受常规治疗,观察组在对照组基础上加用依那普利联合美托洛尔治疗,比较2组临床疗效、治疗前后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)和治疗后2组血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平。结果观察组总有效率为87.1%高于对照组的69.4%,差异有统计学意义(P<0.05)。2组治疗前LVEDD、LVESD、LVEF差异无统计学意义(P>0.05),治疗后2组LVEDD、LVESD水平均低于治疗前,LVEF水平高于治疗前,差异均有统计学意义(P<0.05)。且观察组治疗后LVEDD、LVESD水平均低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗后血清IL-1β、TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。结论依那普利联合美托洛尔治疗慢性心力衰竭疗效显著,并可明显改善心功能及降低血清IL-1β、TNF-α水平。
Objective To observe the clinical efficacy of enalapril combined with metoprolol in chronic heart failure. Methods 124 cases patients with chronic heart failure were randomly divided into observation group and control group, each of 62 cases. Control group was treated by conventional treatment. Observation group, on the basis of conventional treatment, was treated by enalapril combined with metoprolol. Compared the clinical efficacy of two groups. Compared the level of left ventrieu- lar end diastolic diameter （LVEDD）, left ventrieular end systolic diameter （LVESD） and left ventricular ejection fractions （LVEF） before and after treatment of two groups. Compared the level of interleukin-1β （IL-1β）and tumor necrosis factor （TNF-α） after treatment of two groups. Results The total effective rate of observation group （87.1% ） was higher than that of control group （69.4%）, the difference was statistically significant（ P 〈 0.05 ）. The LVEDD ,LVESD ,LVEF before treatment of two groups was no statistically significant（ P 〉 0.05 ）. The level of LVEDD ,LVESD after treatment of two groups was lower than that before treatment（P 〈 0.05 ）, and the LVEF after treatment of two groups was higher than that before treatment （P 〈 0. 05 ）. The level of LVEDD,LVESD after treatment of observation group were lower than that of control group and the level of LVEF after treatment of observation group was higher than that of control group, the difference was statistically significant（ P 〈 0.05 ）. The level of IL-1βand TNF-α after treatment of observation group was lower than that of control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion Enalapril combined with metoprolol in chronic heart failure has an good efficacy, can significantly improved the heart function and reduce the level of IL-1β and TNF-a.
出处
《临床合理用药杂志》
2013年第28期1-3,共3页
Chinese Journal of Clinical Rational Drug Use
