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2011-2012年南京地区无偿献血人群丙型肝炎病毒感染情况分析 被引量:17

Prevalence of hepatitis C virus infections among voluntary blood donors in Nanjing
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摘要 目的:了解南京地区无偿献血人群丙型肝炎病毒(HCV)感染情况。方法:收集2011-2012年129328份无偿献血者的血液标本进行ELISA双试剂抗-HCV检测以及混样核酸检测,并对其结果进行统计分析。结果:2011-2012年南京地区无偿献血者的抗-HCV阳性率为0.25%(327/129 238),HCV RNA阳性率为0.10%(130/129 238)。丙肝病毒的感染与性别和受教育程度不相关(P>0.05),但与献血者的年龄、职业密切相关(P<0.05);同时抗-HCV阳性率与ALT、HCV RNA之间具有一定的相关性,但与乙肝病毒、艾滋病病毒和梅毒感染无关。结论:南京地区无偿献血人群中抗-HCV阳性率较低,且主要为单纯性感染。 Objective:To investigate the prevalences of anti-HCV and HCV RNA among volunteer blood do nors in Nanjing. Method: A total of 129 328 blood samples from volunteer blood donors were recruited from January 2011 to December 2012 in Jiangsu. The anti-HCV assays were performed by ELISA with reagents from two different manufactures and HCV RNA were detected by nucleic acid amplification test with Roche combas s 201. The re suits were analyzed statistically. Result: Anti HCV positive rate among volunteer blood donors in Jiangsu was 0.25%(327/129328). HCV RNA positive rate was 0.10%(130/129 328). There was statistical significance in different ages and occupations and no significance in gender and education level. Conclusion:The anti HCV prevalence is relatively low among volunteer blood donors and HCV infection is mainly simple infection in Nanjing.
机构地区 江苏省血液中心
出处 《临床血液学杂志(输血与检验)》 CAS 2013年第5期718-720,共3页 Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
基金 江苏省卫生厅科技项目(No:H201225) 江苏省预防医学会科技项目(No:Y2012002)
关键词 无偿献血者 丙型肝炎病毒 血清学筛查 核酸检测 volunteer blood donors HCV anti-HCV HCV RNA
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