摘要
目的研究分析晚期阿尔茨海默病患者肺部感染的临床特点及相关因素分析,以降低感染发生率。方法回顾性分析2011年1月-2012年12月152例阿尔茨海默病肺部感染住院患者(感染组)的临床资料,并选择同期住院未感染的152例患者为对照组,统计感染者的病原菌分布,并采用单因素及多因素非条件logistic回归分析其危险因素。结果 152例阿尔茨海默病伴肺部感染患者中分离出病原菌130株,其中革兰阳性菌26株占20.0%、革兰阴性菌78株占60.0%、真菌26株占20.0%;导致阿尔茨海默病患者肺部感染的危险因素包括高龄(>70岁)、合并糖尿病、住院时间长(>4周)、有瘫痪卧床等;而多因素分析进一步表明,合并糖尿病的危险性最大(OR=3.681),其余依次为高龄(>70岁)、住院时间长(>4周)、有瘫痪卧床。结论阿尔茨海默病患者伴肺部感染主要以革兰阴性菌为主,且与多种因素密切相关,临床应注意针对性的开展预防措施,以有效降低感染发生率。
OBJECTIVE To study the clinical features and related ~actors of pulmonary infections in patients with advanced senile dementia, in order to reduce the incidence of infections. METHODS Totally 152 advanced senile dementia patients with lung infections were collected from Jan 2011 to Dec 2012 and the clinical data were analyzed retrospectively, while 152 patients without lung infections were selected as the control group. The distribution of the pathogens and the risk factors for infections were analyzed. RESULTS Totally 130 strains were isolated from 152 advanced senile dementia patients with lung infections, including 26 gram-positive bacteria （20. 0~）, 78 gram-negative bacteria （60.0~）, and 26 fungi（20.0~）. The risk factors for pulmonary infections inciuded the age （more than 70 years old）, combined with diabetes mellitus, hospitalization duration（more than 4 weeks）, paralyzed. The multivariate analysis indicated that combined with diabetes mellitus was the greatest risk factor （OR=3. 681）, followed by the age （more than 70 years old）, hospitalization duration （more than 4 weeks）, paralyzed. CONCLUSION The major pathogens in advanced senile dementia patients with lung infections are gram- negative bacteria, and the infection is closely related to many factors. Reasonable preventative measures should be taken to reduce the incidence of infections effectively.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第19期4645-4646,4649,共3页
Chinese Journal of Nosocomiology
关键词
阿尔茨海默病
肺部感染
临床特点
相关因素
分析
Senile dementia
I.ung infection
Clinical characteristic
Related factor
Analysis
