摘要
目的了解截瘫患者尿路感染常见病原菌的种类分布及常用抗菌药物的耐药特性,为临床合理使用抗菌药物提供依据。方法回顾性分析2010年1月-2011年12月截瘫患者中段尿液标本分离的病原菌及药敏率;标本的接种和培养严格按照《全国临床检验操作规程》进行,用BD细菌鉴定及药敏分析系统对病原菌进行菌种鉴定和药敏分析。结果共检出病原菌246株,其中革兰阴性菌218株、革兰阳性菌20株、真菌8株,分别占88.5%、8.2%、3.3%;革兰阴性菌中大肠埃希菌占41.0%、克雷伯菌属占19.5%、铜绿假单胞菌占11.0%、阴沟肠杆菌占8.1%、不动杆菌属占4.1%;革兰阳性菌以肠球菌属为主占7.8%,两者均呈多耐药性;与同期所有类型的标本分离的相同病原菌药敏相比,耐药性增加明显。结论截瘫患者尿路感染常见病原菌以革兰阴性菌为主,其中大肠埃希菌的比例最高;所检出的病原菌耐药性非常严重,加强细菌耐药性检测合理使用抗菌药物,对控制截瘫患者尿路感染非常重要。
OBJECTIVE To investigate the species of pathogens causing urinary tract infections in the paralyzed patients and analyze the drug resistance to the commonly used antibiotics so as to guide the reasonabli clinical use of antibiotics. METHODS The distribution and drug resistance of pathogens which were isolated in mid-stream urine of paralyzed patients from Jun 2010 to Dec 2011 were analyzed retrospectively. Samples were inoculated and cultured strictly complied with National Clinical Laboratory Procedures, and identification and drug sensitivity analysis of pathogens were executed by BD Phoenix Automated Microbiology System. RESULTS Totally 246 strains were isolated, including 218 strains of gram-negative bacteria, 20 strains of gram-positive bacteria and 8 strains of fungus, accounting for 88. 5%, 8. 2% and 3. 3% respectively. The detected gram-negative bacteria could be subdivided into 41.0% Escherichia coli, 19. 5% Klebsiella, 11. 0% Pseudomonas aeruginosa, 8. 1% Enterobacter cloacae, 4. 1% Acinetobacter; and Enterococcus （7. 8%） was the main detected gram-positive bacteria; both gram-negative and gram-positive bacteria were multi-drug resistant; the drug resistance rate was higher than that of pathogens isolated from other types of samples in the corresponding period. CONCLUSION The common pathogens detected in paralyzed with patients urinary tract infections are gram-negative bacteria, and E. coli takes the highest proportion of gram-negative bacteria; the detected pathogens keep strong drug resistance. To enhance the detection of drug resistance and optimize the medication are extremely important for the control of the urinary tract infections in paralyzed patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第19期4823-4825,共3页
Chinese Journal of Nosocomiology
基金
河南省科技厅科技基金(112300410031)
关键词
截瘫患者
尿路感染
病原菌
耐药性
Paralyzed patient Urinary tract infeetion Pathogen Drug resistance
