摘要
目的探讨血清免疫球蛋白在慢性乙型肝炎患者中的水平变化以及在临床诊治中的意义,为乙型肝炎的临床诊断提供重要依据。方法选取2011年5月-2012年5月慢性乙型肝炎患者146例,并根据病情分为慢性乙型肝炎组84例和慢性重型乙型肝炎组62例,同时选取50名健康体检人员作为对照组,比较3组受检人员的免疫球蛋白(IgG、IgA、IgM)水平;另乙型肝炎患者根据病情进展分为改善组与非改善组,对两组患者的免疫球蛋白水平、总胆红素(TBIL)水平和凝血酶原的活动度(PTA)水平采用t检验进行分析及比较。结果慢性乙型肝炎患者的免疫球蛋白水平经检测明显高于健康对照组人群(P<0.05),且重型乙肝组免疫球蛋白水平高于慢性乙型肝炎组,差异均有统计学意义(P<0.05);改善组患者IgG、IgA、IgM,TBIL和PTA的检测结果分别为(14.26±4.6)g/L、(2.43±0.31)g/L、(2.64±0.13)g/L,(389.44±181.74)μmol/L和(26.29±14.29)%,均明显低于非改善组,差异均有统计学意义(P<0.05)。结论免疫球蛋白(IgG、IgA、IgM)、总胆红素(TBIL)和凝血酶原的活动度(PTA)水平能对乙型肝炎患者进行有效诊断,并对患者的病情变化进行判断,具有重要的临床意义。
OBJECTIVE To explore the change of serum immunoglobin level in patients with hepatitis B and its significance in clinical diagnosis and treatment so as to provide important basis for the clinical diagnosis of hepatitis B. METHODS A total of 146 patients with hepatitis B, who were treated in the hospital from May 2011 to May 2012, were included in the study and were divided into the chronic hepatitis B group with 84 cases and the chronic severe hepatitis B group with 62 cases, meanwhile, 50 healthy people were selected as the control group,then the levels of the serum immunoglobin （IgG, IgA, IgM） were compared between the tree groups; hepatitis B patients were divided into the improvement group and the non-improvement group according to the progression of illness, the level of serum immunoglobin, level of total bilirubin, and the prothrombin activity were compared between the two groups with the use of t test. RESULTS The levels of serum immunoglobin （IgG, IgA, IgM） tested were significantly higher in the chronic hepatitis B group than in the control group, which were significantly higher in the chronic severe hepatitis B group than in the chronic hepatitis B. The levels of the tested IgG, IgA, IgM, TBIL and PTA of the improvement group were respectively （14.26±4.6）g/L, （2.43±0.31） g/L, （2.64±0.13）g/L,（389.44±181. 74）tLmol/L, and （26. 29± 14. 29）%, which were significantly lower than those of the control group, the difference was significant （P 〈 0. 05）. CONCLUSION The determination of the levels of serum immunoglobin （IgG, IgA, IgM）, TBIT, and PTA has great significance in the clinical diagnosis as well as the judgment of illness condition.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第20期5110-5111,5120,共3页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生科研基金(2008B167)
