摘要
目的探讨乳腺癌中的HER-2的表达及意义,研究患者的腋窝淋巴结转移、TNM分期、组织学类型、PR和ER间的关系以及HER-2过度表达的药物治疗策略。方法选择该院2008年5月至2012年5月收治的确诊为乳腺癌的84例患者,对这84例患者进行检查,并将其病情分类,应用免疫组织化学(SP)法对其进行检测,将结果与正常乳腺组织的样本进行对照。结果乳腺癌患者乳腺组织内的HER-2因子受体要高于正常的乳腺组织,差异有统计学意义(P<0.05),患者乳腺癌组织中HER-2受体的表达与其TNM分期、组织学类型无关(P=0.256、0.157)。结论 HER-2在乳腺癌的发生发展中起关键作用,能够为乳腺癌患者的诊断、多靶向治疗提供依据。
Objective To study the expression of HER-2 expression in breast cancer and the significance ,and to look into rela-tions between axillary lymph node metastasis in patients ,TNM ,T staging ,histological type ,PR and ER as well as drug treatment strategy of HER-2 over expression .Methods Eighty-four cases of patients admitted by this hospital from May 2008 to May 2012 diagnosed with breast cancers were selected ,84 patients were examined in this hospital ,and conditions of patients were classified , they were tested by use of Streptavidin-Peroxidase （SP method） ,test results and samples of normal breast tissues were compared . Results The level of HER-2 factor receptor in mammary gland tissues of patients with breast cancer was higher than that within normal breast tissue ,the difference was statistically significant （P〈 0 .05） ,the expression of HER-2 receptor in patients with breast cancer tissue was unrelated to TNM staging ,histological type （P values were 0 .256 and 0 .157 respectively） .Conclusion HER-2 plays a key role in the identifying the generation and development of the breast cancer ,and it can provide the basis for the diagnosis ,multi-targeted therapy of patients with breast cancers .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第29期3498-3499,3502,共3页
Chongqing medicine
