摘要
为研究黄连解毒汤(HLJDT)体内抗肿瘤作用,将健康雌性昆明种小鼠50只(体重18～22 g),随机分为对照组,环磷酰胺组(CTX),黄连解毒汤大、中、小剂量组(22.0、11.0、5.5 g·kg-1)。通过建立小鼠S180肉瘤模型,观察黄连解毒汤对小鼠生存质量、胸腺指数、脾脏指数和肿瘤细胞形态影响,并测定荷瘤小鼠生存期、生存率。结果表明,黄连解毒汤大剂量组抑瘤作用显著(P<0.05),可延长荷瘤小鼠寿命,改善生存质量;黄连解毒汤大、中、小剂量组脾脏(胸腺)指数与对照组相比没有显著差异;细胞形态学观察显示黄连解毒汤大、中剂量组肿瘤细胞变形严重;中剂量组与大剂量组小鼠生存率明显高于对照组。
To study the antitumor effects in vivo of Huang tianjiedu Decoction（HLJDT）. The mice model of S180 sarcoma of tumor bearing mice were established and then the mice were given Huang- lianjiedu Decoction by intragastric administration.Antitumor activities were tested in mice with experimental tumor S180 in vivo. The quality of life, thymus index, spleen index, morphology of S180 cancer cell and survival rate of tumor-bearing mice were evaluated. And life time and survival rate were evaluated. On the antitumor effects the difference between high dose group and the control group were significant （P〈0.05）;There were no significant differences between the antitumor agents groups and the control group in thymus index and spleen index; Cell morphology showed the tumor cells for middle and high dose group can induce severe deformation; Survival rate for middle and high dose group was significantly higer than control group. HLJDT has obvious antitumor effects on S180 implanted mice in vivo.lt can extend the life time and improve the quality of life.
出处
《东北农业大学学报》
CAS
CSCD
北大核心
2013年第9期63-67,共5页
Journal of Northeast Agricultural University
基金
沈阳医学院科技基金项目(20133054)
关键词
黄连解毒汤
S180
体内
抗肿瘤作用
Huanglianjiedu Decoction （HLJDT）
180
in vivo
antitumor activity
