摘要
目的探讨2型糖尿病肾病患者^99Tc^m-DTPAGFR测定的时间影响及GFR对2型糖尿病肾功能异常早期诊断的临床意义。方法招募健康志愿者11名，其中男6名，女5名，年龄47～79（61．45±7．90）岁；社区2型糖尿病肾病患者56例，其中男31例，女25例，年龄45～75（60．98±6．96）岁，均应用^99Tc^m-DTPA肾动态显像测定GFR。分别取注药后第2分钟和第3分钟图像勾画ROI，根据Gates分析方法，计算总肾及分肾GFR。利用SPSS15．0软件对数据进行Pearson相关分析和两样本t检验。结果2型糖尿病肾病患者的GFR与SCr[（84．90±14．38）bunol／L]呈负相关：注射^99Tc^m-DTPA后第2分钟双肾、左肾和右肾GFR均与SCr呈负相关（r=-0．599、-0．553和-0．529，均P〈0．001）；第3分钟双肾、左。肾和右肾GFR也均与SCr呈负相关（r=-0．652、-0．636和-0．470，均P≤0．001）。2型糖尿病。肾病患者双肾、左肾和右肾第3分钟GFR分别为（69．77±11．00）、（33．12±5．74）和（37．34±9．81）ml／min，低于健康对照组[（97．89±5．98）、（46．60±4．91）和（51．28±4．20）ml／min；t=-8．212、-7．233和-4．069，均P〈0．001]。结论建议对2型糖尿病肾病患者选择注射^99Tc^m-DTPA后第3分钟的放射性计数测定GFR；GFR测定对糖尿病肾病患者肾功能异常早期诊断具有重要意义。
Objective To study the changes of GFR measured in different time intervals after the injection of 99Tcm-DTPA and to evaluate the clinical value of GFR in patients with type 2 diabetes. Methods Eleven healthy volunteers （ 6 males, 5 females ; mean age （ 61.45± 7.90） years, age range ： 47- 79 years ） and 56 patients with type 2 diabetes （31 males, 25 females; mean age （60.98±6.96） years, age range： 45- 75 years） were recruited. 99Tcm-DTPA was used to measure GFR for all subjects. ROI was drawn at 2 and 3 rain post-injection and GFR was calculated by Gates method. Two-sample t test and Pearson correlation analysis were performed with SPSS 15.0. Results SCr （（84.90±14.38） μmol/L） was significantly correlated with GFR in patients with type 2 diabetes. There was negative correlation between SCr and GFR for both, left and right kidneys at 3 min post-injection （r=-0.652, -0.636, -0.470, all P≤0.001） and at 2 rain post-injection （r=-0.599, -0.553, -0.529, all P〈0.001）. Total GFR, GFR for left kidney and GFR for right kidney at 3 rain post-injection in diabetes group （ （ 69.77± 11.00 ） , （ 33.12 ± 5.74 ） , （ 37.34 ± 9.81 ） ml/min） were lower than those in control group （ （97.89±5.98）, （46.60±4.91）, （51.28±4.20） ml/min; t=-8.212, -7.233, -4.069, all P〈0.001）. Conclusions To calculate the GFR of the patients with type 2 diabetes, 3 rain post-injection is the optimal time. Measurement of GFR by 99Tcm-DTPA is useful in early diagnosis of diabetic nephropathy.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2013年第5期355-357,共3页
Chinese Journal of Nuclear Medicine and Molecular Imaging
