摘要
目的探讨三维适形放射治疗联合吉西他滨治疗老年晚期胰腺癌的近期疗效及安全性。方法将68例老年晚期胰腺癌患者随机分入对照组（32例）和观察组（36例）,对照组患者给予三维适形放射治疗,总剂量DT45-54Gy。观察组患者在三维适形放射治疗的同时给予吉西他滨同步化疗,每周600mg/m2。比较两组近期疗效、1年和2年生存率、疼痛评价及不良反应。结果两组患者总有效率及1年生存率差异均无统计学意义（P〉0.05）,观察组患者2年生存率显著高于对照组（P〈0.05）;观察组患者疼痛改善情况显著优于对照组（P〈0.05）;观察组患者骨髓抑制发生率显著高于对照组（P〈0.05）,但经对症处置后均顺利完成疗程。结论三维适形放射治疗联合吉西他滨治疗老年晚期胰腺癌可延长患者生存时间,减轻疼痛,不良反应可耐受。
Objective To explore the short term effect and safety of three-dimensional conformal radiation therapy combined with gemcitabine in treatment of elderly advanced stage pancreatic carcinoma. Methods 68 elderly cases with advanced pancreatic carcinoma were randomly divided into control group （32 cases） and experience group （36 cases）. Control group were given three-dimensional eonformal radia- tion therapy with a total dose of 45 -54Gy. Experience group received three-dimensional conformal radiation therapy combined with gemeitabine treatment. Gemcitabine at a dose of 600mg/m2 was given weekly. Short term effect, 1 and 2 year survival rates, pain measurement and toxic side effects were compared between two groups. Results There were no significant difference of effect rate of treatment and 1 year survival rate be- tween two groups （ P 〉 0. 05 ）. 2 year survival rate in experience group was much higher than that in control group （ P 〈 0. 05 ）. Pain improvement in experience group was superior to control group （ P 〈 0. 05） ; Com- parison with control group, the occurrence of myelosuppression greatly increased （ P 〈 0. 05 ）, while the all the patients undergo the therapeutic period smoothly after symptomatic treatment. Conclusions Three- dimensional conformal radiation therapy combined with gemeitabine for elderly advanced stage pancreatic carcinoma prolong survival time and relieve pain. The patient＇s tolerance was aeeeptaele.
出处
《中国肿瘤临床与康复》
2013年第9期1009-1011,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胰腺肿瘤
放射疗法
适形
吉西他滨
药物疗法
联合
Pancreatic neoplasms
Radiotherapy
conformal
Gemcitabine
Drug therapy
combination
