摘要
目的:分析2型糖尿病下肢动脉硬化不同程度患者的骨密度变化,探讨2型糖尿病和骨质疏松之间的相关性。方法:本研究选取2型糖尿病患者108例,其中男56例,女52例,按下肢动脉血管病变严重程度分为无病变组、轻度病变组、中重度病变组,同时采用双能X线吸收仪测定正位腰椎、左侧股骨及左前臂骨密度变化,并结合患者的性别、年龄、体质指数、病程、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、空腹血糖、糖化血红蛋白(HbA1C)、尿白蛋白进行相关性分析。结果:①无病变组左股骨骨密度显著高于轻度、中重度病变组(均P<0.05),轻度病变组左股骨颈骨密度显著高于中重度病变组(P<0.05)。无病变组左前臂骨密度显著高于轻度、中重度病变组(均P<0.05),轻度病变组左前臂骨密度显著高于中重度病变组(P<0.05)。且糖尿病动脉硬化程度越重,骨密度下降越明显。②无病变组血总胆固醇显著低于轻度、中重度病变组(均P<0.05)。甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、HbA1C、尿白蛋白:中重度病变组与无病变组及轻度病变2组均存在显著差异(P<0.05)。③随着BMI值升高,骨密度值也显著升高(P<0.05);随着病程增加、动脉硬化积分及HbA1C值升高,骨密度值显著降低(均P<0.05)。结论:2型糖尿病下肢血管病变与骨密度有一定相关性。有动脉硬化的患者也存在骨密度降低风险。
Objective ：To discuss the relationship between osteoporosis and arteriosclerosis of lower-extremity by analyzing degrees of bone mineral density（BMD）in patients with type 2 diabetes combined with arteriosclerosis of lower extremity.Methods：One hundred and eight patients with type 2 diabetes including 56 male cases and 52 female cases.The arterial wall endometrial thickness ,luminal diameter,plaque and blood flow of lower extremity were dectected by ultrasound.And the patients were divided into 3 groups （non-arteriosclerosis group, mild group,moderate/severe group）according to the severity of lower-extremity artery disease.BMD of lumbar spine,left femur,left forearm were measured by dual cherty X-ray absorptiometry.All of the subjects determined clinical index and analyzed risk factors.Results：（1）In the non-arteriosclerosis group,the BMD of left femur,left forearm were both higher than the other 2 groups.The mild group of BMD in the left femur,left forearm were higher than the moderate/severe group.The more severe arteriosclerosis,the lower the BMD was. （2）In the non-arteriosclerosis group total cholesterol was lower than other two groups （P〈0.05）.TG,HDL,LDL, BG,glycosylated hemoglobin （HbA1C）,UA in moderate/severe group had significant difference with the other 2 groups（P〈0.05）.With the increase of body mass index,the BMD was higher（P〈0.05）.With the increase of diabetes duration,arteries atherosclerosis extent integral and HbA1C,decrease in BMD （P〈0.05）.Conclusion：Lower extremity vascular disease of diabetes may related to BMD.Early determination of arteriosclerosis have risks of reduction of BMD.
出处
《中日友好医院学报》
2013年第5期276-280,共5页
Journal of China-Japan Friendship Hospital
关键词
2型糖尿病
下肢动脉硬化
骨密度
相关性
type 2 diabetes
arteriosclerosis of lower extremity
bone mineral density
correlation
