摘要
目的探讨纳米羟基磷灰石／聚酰胺66（n-HA／PA66）生物活性人工Cage植骨融合术治疗腰椎退变的临床疗效。方法从2007年6月～2012年2月，对腰椎退变失稳定性疾患，需要后路手术＋椎间植骨融合的患者，采用n-HA／PA66复合生物活性椎间Cage植骨融合、经椎弓根钉棒系统内固定，共61例70个椎间隙。用M-JOA评分的症状改善率评价患者治疗效果；术前、术后1周及3月、6月、12月分别摄x射线片及CT，观察椎体间高度、融合节段前凸弧度及植骨融合情况。结果随访6～48个月（平均28个月），术后3-4个月开始产生骨融合，术后12月69个节段得到骨性融合（98．57％），椎间隙高度无降低，症状无复发。结论纳米羟基磷灰石／聚酰胺66（n_HA／PA66）复合椎间Cage植骨融合内固定术，可有效重建退变腰椎的稳定性，Cage内外的植骨可与相邻椎体有效融合并形成完整整体，是一种理想的椎间植骨融合方式。
Objective To investigate the reablement efficacy of the lumbar spine stability after the treatment by the bio active Cage by nano-hydroxyapatite/polymide 66 （n-HA/PA66） vertebrae with bone graft fusion and fixation for the pa-tients losed lumbar stability because of cataplasis. Methods From June 2007 to Feb 2012, the 61 cases, total 70 inter vertebral space, losed lumbar stability were treated by meta-approach decompress, intervertebra bone graft fusing in the bioactive Cage by nano-hydroxyapatite/polymide 66 （n-HA/PA66） to re-establishment vertebral stability, and fixation locked. The improvement rate by M-JOA score is used to appraise the therapeutic efficacy. And the actinogram and CT were taked respectively to observe the intervertebra height, the pine radian, and fusion information, when Preoperative and after operation 1 week, and 3, 6, 12 month. Result We get 28 months follow-up in average, from 6 to 48. All the patients get backleg pain obviously lessen or vanishing without any serious complication. The fineness rate by M-JOA score is 90.2%. And the Cage graft fusion was come to forming in 3 or 4 months. And 69 of the 70 （98.57%） intervertebral space have get bone fusion completely when 12 months aiter operation. The the intervertebra height and the pine radian have no lose. No recidivation happened in the follow-up visit. Conclusion For the lumbar spine unsteadiness, this bio active Cage with bone graft and fixion, is a satisfactory modus to get intervertebral fusion, because it can get the reablement of the vertebra stability, the I-B height and texture validly, and get fusion with the close vertebra together.
出处
《生物骨科材料与临床研究》
CAS
2013年第5期16-18,共3页
Orthopaedic Biomechanics Materials and Clinical Study
