摘要
目的 比较氯丙嗪、奥氮平和齐拉西酮对慢性精神分裂症患者认知功能的影响.方法 将120例慢性精神分裂症患者按数字表法随机分为三组,分别为氯丙嗪组（38例）、奥氮平组（41例）和齐拉西酮组（41例）,于入组前、治疗后第12周时采用简明精神病量表（BPRS）、个人和社会功能量表（PSP）、威斯康星卡片分类测验（WCST）、修订韦氏成人智力量表（WAIS-RC）进行随访评定.结果 经12周治疗,三组治疗前后BPRS测试结果差异均有统计学意义[F（5,41） =6.49,P＜0.05],而三组之间差异无统计学意义；第12周末,齐拉西酮组和奥氮平组WCST[F（5,47）=18.30,P＜0.05]、PSP[F（5,47）=10.02,P＜0.05]和WAIS-RC[F（5,47） =6.74,P ＜0.05]评分显著优于氯丙嗪组.结论 氯丙嗪、奥氮平和齐拉西酮均可改善慢性精神分裂症患者精神症状和认知功能,齐拉西酮和奥氮平对认知功能损害的改善效果优于氯丙嗪.
Objective To compare the effects of chlorpromazine,olanzapine and ziprasidone on cognitive function of patients with chronic schizophrenia.Methods A total of 120 patients with chronic schizophrenia were randomly divided into chlorpromazine group（n =38）,olanzapine group（n =41） and ziprasidone group（n =41）.The patients were subjected to the Brief Psychiatric Rating Scale（BPRS）,Wisconsin Card Sorting Test（WCST）,Personal and Social Function of Scale （PSP） and Wechsler Adult Intelligence Scale-Revised （WAIS-RC） assessment respectively,before and after treatment for 12 weeks.Results After treatment for 12 weeks,the score of BPRS significantly decreased in three groups compared with that before treatment [F （5,41） =6.49,P ＜ 0.05].After treatment for 12 weeks,the results of WCST [F （5,47） =18.30,P ＜ 0.05],PSP [F （5,47） =10.02,P ＜ 0.05] and WAIS-RC [F（5,47） =6.74,P ＜ 0.05] test in ziprasidone and olanzapine group were better than that of chlorpromazine group.Conclusion Chlorpromazine,olanzapine and ziprasidone could improve the cognitive function and mental syndrome of patients with chronic schizophrenia.In addition,the effect of ziprasidone and olanzapine was better than chlorpromazine.
出处
《中国基层医药》
CAS
2013年第21期3205-3207,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省丽水市科技计划项目（丽科[2011]55号-9）
