摘要
目的观察急性心肌梗死(AMI)患者溶栓前后甲状腺激素水平的变化,并且探讨其临床意义。方法 AMI溶栓患者48例,以门诊体检40例作为正常对照组;所有患者均用化学发光免疫分析仪分别测定溶栓前、溶栓后48小时血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)以及促甲状腺激素(TSH)。结果①AMI组溶栓前血清甲状腺激素水平与正常对照组比较差异有统计学意义(P<0.05):T3(1.01±0.35)nmol/L vs(1.71±0.37)nmol/L;②溶栓后48小时甲状腺激素水平较溶栓前明显升高,差异有统计学意义(P<0.05):T3(1.01±0.35)nmol/L vs(1.72±0.43)nmol/L。结论 AMI早期即出现低甲状腺激素水平,溶栓治疗后随着血管再通、各种有效治疗后逐渐恢复正常,因此,甲状腺激素水平可以作为AMI患者心肌功能恢复临床评估指标。
Objective To detect thyroid hormone levels change and its clinical significance for patients with acute myocardial infarction（AMI）before and after thrombolysis.Methods The serum triiodothyronine（T3）,thyroxine（T4）and thyrotropic-stimulating hormone（TSH）levels were measured by chemiluminescent immunoassay analyzer in 48 AMI outpatients and 40normal controls,and all patients were determined serum T3,T4,and TSH,respectively before and after thrombolytic 48hours.Results ①The serum T3 level in AMI group was significantly lower than that in normal control group,T3（1.01±0.35）nmol/L vs（1.71±0.37）nmol/L（P 0.05）;②48hthyroid hormone level after thrombolysis was significantly higher than that before thrombolysis,T3（1.01±0.35）nmol/L vs（1.72±0.43）nmol/L（P 0.05）.Conclusion Serum T3 level in the early AMI patients is lower,and it gradually returns to normal after thrombolytic therapy.Therefore,thyroid hormone levels can be considered as the clinical assessment indicators of myocardial function recovery in AMI patients.
出处
《临床荟萃》
CAS
2013年第10期1093-1094,1097,共3页
Clinical Focus
关键词
心肌梗死
甲状腺激素类
血栓溶解疗法
myocardial infarction
thyroid hormones
thrombolytic therapy
