摘要
目的研究黄芪饮治疗过敏性鼻炎的疗效,为简化中药组方提供理论依据。方法采用致敏豚鼠为动物模型,用小鼠皮肤被动过敏试验验证造模成功后给药1周,通过病理免疫指标观察治疗效果。结果病理切片显示健康组细胞整齐排列有序,无嗜酸性粒细胞浸润,模型对照组则有大量嗜酸性粒细胞浸润,黄芪饮高、中、低剂量治疗组及盐酸西替利嗪片药物对照组与模型对照组比较无明显差异;与模型对照组比较,黄芪饮高、中、低剂量治疗组和盐酸西替利嗪片药物对照组中白介素-12水平呈不同程度下降,差异有统计学意义(P<0.01)。结论黄芪饮对过敏性鼻炎有一定治疗作用,且服用简单、方便。
Objective To study the effect of Huangqiyin on allergic rhinitis, and provide a theoretical basis for the sim- plified traditional Chinese directions. Methods Sensitized guinea pigs were adopted as animal model,the medicine was adminis- trated for 1 week after the model was succeeded, and the indexes of pathological immune were examined to observe the treatment result. Results The healthy group revealed healthy cells arranged in neat and orderly,without eosinophil infiltration by biopsy the while model group showed a large number of eosinophils, and there was no statistically significant differenee between the Huangqiyin treatment group （high dosage, middle dosage,low dosage ） and the control group of cetirizine hydrochloride tablets and the model group;compared with the model group,interleukin-12 levels in Huangqiyin group （high dosage, middle dosage,low dosage ） and the control group of cetirizine hydrochloride tablets decreased differently with statistically significant difference （P〈0.01）. Conclusion Huangqiyin has effect in treating allergic rhinitis, and it is easy to be taken.
出处
《现代医药卫生》
2013年第18期2721-2722,2724,共3页
Journal of Modern Medicine & Health
关键词
鼻炎
变应性
常年性
中药疗法
黄芪
饮片
白细胞介素12
药效动力学
Rhinitis, allergic, prennial/Zhong yao liao fa
Astragalus membranaceus
Herbal pieces for decoction
Interleukin-12
Pharmacodynamies
