摘要
阻塞性睡眠呼吸暂停综合征(OSAS)是一种以睡眠时出现上气道咽腔水平反复的塌陷为主要特征,造成间断低氧、反复觉醒、睡眠片段化的睡眠疾病,其发病机制仍未明确。但越来越多的证据表明OSA与炎症密切相关,肥胖、间断低氧、机械应力损伤是造成OSA炎症的主要因素。系统性和局部性的炎症可能是OSA发病机制的原因之一。
Obstructive sleep apnea syndrome（OSAS） is characterized by recurrent upper airway collapses occurring at pharynx level during sleep and results in intermittent hypoxia,arousal and sleep fragment.Nonetheless,underlying pathogenesis for OSA is still unclear.There is mounting evidence indicating that OSA is related to infammation.Obesity,hypoxia and repeated mechanical trauma are the main pathogenesis of infammation in patients with OSA.Systemic and local infammations are possibly involved in the pathogenesis of OSA.
出处
《分子诊断与治疗杂志》
2013年第5期353-356,共4页
Journal of Molecular Diagnostics and Therapy
基金
国家重点基础研究发展计划(973计划)项目(2012CB517802)资助
关键词
阻塞性睡眠呼吸暂停
炎症
肥胖
上气道
Obstructive sleep apnea
Infammation
Obesity
Upper airway
