摘要
目的分析小剂量米氮平与劳拉西泮治疗慢性失眠症的临床疗效。方法将72例慢性失眠症患者随机分为2组,A组35例采用劳拉西泮治疗,B组37例采用米氮平治疗,观察治疗后1周、2周睡眠质量改善情况及不良反应发生情况。结果 B组治疗优良率高于A组(P<0.05);治疗1周、2周后,B组匹兹堡睡眠质量指数量表(PSQI)评分均低于A组(P<0.01);两组不良反应发生率比较差异无统计学意义(P>0.05)。两组均无明显的不良反应发生。结论小剂量米氮平治疗慢性失眠症疗效优于劳拉西泮,患者睡眠质量显著改善。
Objective To analyze the effect of low-dose of mirtazapine and lorazepam in the treatment for chronic insomnia.Methods 72 cases of chronic insomnia patients w ere randomly divided into tw o groups,35 cases in A group w ere given lorazepam,37 cases in B group w ere given olanzapine,to observe sleep quality improvement and adverse reactions after 1 and 2 w eeks treatment.Results The excellent rate of B group w as higher than that of A group（P 0.05）; after 1 and 2 weeks treatment,PSQI scores of B group were lower than that of A group（P 0.01）; the incidence of adverse reactions betw een the tw o groups had no significant difference（P0.05）.Conclusion Low-doses of mirtazapine treatment for chronic insomnia is more effective than lorazepam,it can significantly improve sleep quality,it is safe and reliable.
出处
《实用药物与临床》
CAS
2013年第9期821-823,共3页
Practical Pharmacy and Clinical Remedies
