摘要
目的探讨血清胱抑素C(Cys C)和尿微量清蛋白(mAlb)检测与中毒程度及肾脏早期损伤的关系。方法收集2010年1月至2012年12月在莆田市第一医院收治急性有机磷农药中毒(AOPP)患者159例,按中毒程度分为轻度组60例、中度组53例、重度组46例,选择同期来院体检的健康志愿者50例为健康对照组,监测入院时,治疗1、3、5d的血清Cys C和mAlb指标。结果 3个AOPP组血清Cys C和尿mAlb在入院时已显著高于健康对照组,治疗后1d3个组别的血清Cys C和尿mAlb达到高峰,后逐渐下降,治疗5d时,各组的血清Cys C和尿mAlb水平已明显下降。结论血清Cys C和尿mAlb有良好一致性,联合检测对监测早期肾功能损害具有明显的临床意义。
Objective To investigate the clinical value of serum Cystatin C （Cys C） and urine microalbumin （UmAlb） in patients with acute organophosphorus pesticide （AOPP）. Methods A total of 159 cases of AOPP pa- tients were divided into mild group for 60 cases,moderate group for 53 cases and sev＇ere group for 46 cases and detec ted for serum Cys C and UmAlb levels 1,3 and 5 days after admission. 50 healthy subjects were enroll as control group. Results Serum Cys C and UmAlb levels in patient groups at admission were significantly higher than control group. Oen day after treatment, serum Cys C and UmA lb levels in patient groups reached peak value, which then were decreased. Five days after treatment,serum Cys C and UmAlb levels in patient group decreased significantly. Conclu- sion Serum Cys C and UmAlb might be with fine consistency,combined detection of which could be with obvious clinical significance for monitoring early impairment of renal function.
出处
《检验医学与临床》
CAS
2013年第19期2522-2523,共2页
Laboratory Medicine and Clinic
关键词
急性有机磷农药中毒
胱抑素C
尿微量清蛋白
acute organophosphorus pesticide poisoning
cystatin C
urine microalbumin
