摘要
以天然高分子壳聚糖为原料,通过在壳聚糖2位—NH2上引入部分疏水性烷基,在6位—OH和2位—NH2上引入亲水性羟乙基,制得N-月桂基-O,N-羟乙基壳聚糖(LGC)两亲性衍生物,分别用FTIR、1HNMR和元素分析等技术对其结构进行表征.此壳聚糖衍生物在水相中自组装形成胶束,以芘为荧光探针研究了其自聚集行为,结果表明制得的自聚体具有较小的临界胶束浓度(CMC为1.67×10-2,mg/mL),并用此壳聚糖胶束对疏水性染料噻唑橙(TO)进行了包覆,发现包覆后染料的荧光强度显著增强.
ith biopolymer chitosan as raw material, the amphiphilic derivative of N-lattryl-O, N-hydroxyethyl, chitosan （LGC） was synthesized by the introduction of hydrophohic moietie of alkyl groups to --NH2 at 2, and the intro duction of hydroxyethyl groups as the hydrophilic moieties to --OH at 6 and--NH2 at 2. The chemical structure of the de- rivative was characterized via FTIR, HNMR and elemental analysis. The LGC could self-aggregate to form micelle with a critical micelle concentration （CMC）at 0.0167mg/mL in the aqueous phase. The hydrophobic dye thiazole orange （TO）was encapsulated with this amphiphilic chitosan derivative. The prepared nanoparticles （LGC/TO）showed a remarkable en- hancement of fluorescence intensity compared with TO in aqueous solution.
出处
《天津城市建设学院学报》
CAS
2013年第3期211-214,225,共5页
Journal of Tianjin Institute of Urban Construction
基金
国家自然科学基金(51178289)
教育部科学技术研究重点项目(211005)
关键词
壳聚糖
两亲性
胶束
噻唑橙
chitosan
amphiphilicity
micelle
thiazole orange （TO）
