摘要
目的研究中医药干预治疗视网膜静脉阻塞(RVO)并发黄斑水肿的临床疗效。方法 60例并发黄斑水肿的RVO患者,随机分为中医药治疗组(20例20眼)、玻璃体腔内注射Ranibizumab治疗(IVR)组(20例20眼)与IVR联合中医药治疗组(20例20眼)。治疗3个疗程后,记录并分析所有患者的临床疗效。结果在纳入的60例60只眼中,应用中医药治疗的20例患者的总有效率为50%,应用IVR治疗的20例患者的总有效率为65%,而在应用中医药加IVR联合治疗组的20例患者中,总有效率最高,可达到80%,表明联合治疗效果最佳。治疗3个疗程后,各组视野平均缺损(MD)较治疗前均改善(P<0.05)。中医药治疗组(t=3.016,P<0.01)在改善RVO患者平均视野缺损方面,疗效优于IVR组(t=2.627,P<0.05);而IVR联合治疗组的临床疗效最佳(t=3.098,P<0.01)。治疗3个疗程后,各组ERG的b波振幅均上升(P<0.01)。与中医药治疗组(t=2.89,P<0.01)及IVR组(t=3.44,P<0.01)相比,IVR联合治疗组对RVO患者的视功能恢复效果最佳(t=4.084,P<0.01)。结论中医药干预治疗视网膜静脉阻塞并发黄斑水肿有一定的临床疗效,并有较好的经济效益;IVR联合中医药治疗可标本兼治,取得较好的治疗效果。
OBJECTIVE To study the effect of traditional Chinese medicine in the treatment of patients with macular edema secondary to retinal vein occlusion （RVO）. METHODS Sixty patients with macular edema were ran domly divided into three groups, the first group with twenty eyes in twenty patients, treated with traditional Chinese medicine, the second group with twenty eyes in twenty patients, treated with an intravitreal injection of ranibizumab （IVR） and the third group also with twenty eyes in twenty patients, treated with combined treatment. All patients were recorded and analyzed changes of clinical effects after 3 courses of treatment. RESULTS After 3 courses of treatment, the total effective rate in the first group treated with traditional Chinese medicine was 50%, the second group treated with IVR was 65% while the figure in the third group treated with combined treatment was as high as 80% which showed that combined treatment was the most effective. All three groups showed improvement of mean deviation （MD） after 3 courses of treatment （P〈0.05）and such improvement was more notable in the first group （t=3.016, P〈0.01 ） when compared with the IVR group （t=2.627 ,P〈0.05 ）, and was most prominent in the third group （t=3.098 ,P〈0.01 ）. All three groups showed marked restoration of ERG b-wave amplitudes after 3 courses of treatment （P〈0.01）and such restoration was also most prominent in the third group （t=4.084,P〈0.01 ）when compared with the first group （t=2.89,P〈 0.01 ） and the second group （t=3.44 ,P〈0.01 ）. CONSLUSIONS Traditional Chinese medicine could effectively im prove the therapeutic effect in patients with macular edema secondary to retinal vein occlusion, and it also had great economic benefit. The combination of IVR, the modern technique, and our traditional Chinese medicine could effectively treat both principal and secondary aspect of the disease and showed great potential in the clinical use.
出处
《中国中医眼科杂志》
2013年第5期328-332,共5页
China Journal of Chinese Ophthalmology
