摘要
采用随机双盲、安慰剂对照方法 ,开展保心康治疗气阳虚型充血性心力衰竭 (CHF)的临床研究。1 1 7例中医辨证为气阳虚型CHF患者随机分为观察组和安慰剂对照组 ,其中观察组 90例 ,对照组 2 7例 ,观察组口服保心康片 (4片 /次 ,3次 /d) ,对照组给等剂量的安慰剂 ,疗程为 2周 ,观察两组患者的中医证候及西医症状、体征、心功能分级和血液流变学、血脂、血气分析、心胸比率、心电图等指标。结果显示 :保心康的中医证候总有效率为 87.8% ,证候积分下降 ,心衰积分降低 ,心衰积分总有效率为 76.7% ,心功能疗效总有率效为 81 .1 % ,血液流变学指标改善 ,以上指标与安慰剂对照组比较有统计学意义。
A randomized,double_blind and placebo-controlled trial was applied to evaluate the effects of Baoxinkang Tablet(BT),a compound prescription made of Chinese herbal medicine, on congestive heart failure (CHF).One hundred and seventeen cases of CHF with qi_and yang_deficiency syndrome were randomly allocated to treatment group and control group. The treatment group(N=90) were given BT(4 Tablets each time,3 times per day)for 2 weeks and the control group (N=27) were given the same dosage of placebo. The scores of traditional Chinese medicine (TCM) syndromes,symptoms and signs were calculated. The indexes of cardiac function,blood rheology,blood lipid,blood gaseous analysis,cardiothoracic ratio and electro cardiogram were observed.Results showed that in the treatment group the total effective rates of TCM syndromes was 87.8%, the score of syndromes was decreased and the main symptoms were markedly improved, the total effective rate of heart failure score was 76.7%, the score of heart failure and the score of each symptom were all decreased,the total effective rate of heart function was 81.1%; the indexes of the blood rheology were improved.The differences of the above indexes were significant as compared with the control group. BT had no effect on blood glucose, blood lipid and the function of the liver and the kidney.No obvious toxic of side effects were found in the study.
出处
《中药新药与临床药理》
CAS
CSCD
2000年第5期261-265,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家中医药管理局医政司胸痹急症协作组课题(960801)
广东省中医药管理局课题(950510)
