摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)自发现至今被认为能够导致多种疾病的发生,包括消化性溃疡、慢性胃炎、胃癌以及胃淋巴细胞相关性肿瘤.近年来传统三联疗法(质子泵抑制剂+两种抗生素)对于H.pylori根除率明显下降,这与细菌耐药性的增强有关.在传统三联疗法基础上添加益生菌能够有效的提高H.pylori根除率,同时降低不良反应的发生.其机制可能为益生菌能够修复H.pylori引起的化学屏障、生物屏障、机械屏障以及免疫屏障的破坏,恢复消化系正常防御功能,从而辅助H.pylori根除.此文将就益生菌修复H.pylori相关消化系屏障功能破坏的具体机制进行综述.
Helicobacter pylori （H. pylori） is closely associated with many gastrointestinal diseases, including peptic ulcers, chronic gastritis, gastric cancer and gastric mucosa-associated lymphoid tumors. In recent year, traditional triple therapy for H. pylori eradication has become less effective than the past, which is related to the resistance of bacteria. The addition of probiotics into the regimen has been proved to be able to significantly enhance the eradication rate and reduce side effects. Probiotics increase the eradication of H. pylori by recovering the damage of the chemical barrier, biological bar- rier, mechanical barrier and immune barrier.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第28期2981-2986,共6页
World Chinese Journal of Digestology
关键词
幽门螺杆菌
益生菌
黏膜屏障
Helicobacterpylori
Probiotic
Intestinalmucosal barrier
