摘要
目的调查暴露后人群接种狂犬病疫苗(Rabies Vaccine for Human Use,RabV)的免疫学效果。方法 122例暴露后,病例接种RabV后应用快速荧光灶抑制试验检测抗体产生情况。结果 3剂免疫后抗体阳性率达99.1%,5剂免疫后抗体阳性率为100%;不同性别病例抗体几何平均滴度差异无统计学意义。青少年接种RabV的应答较快,中老年接种RabV的应答较慢。结论对要确定是否需要接受RabV加强接种以建立一个可接受的暴露前免疫状态,对有免疫缺陷等身体状况特殊者,有必要检测接种RabV后的中和抗体,对未产生抗体者应及时补充免疫,确保免疫学效果。
Objective To investigate the immunology effect in post-exposure population after inoculation of rabies vaccine for human use （RabV） Methods Analyze the antibody of 122 exposure cases vaccinated by RabV based on rapid fluorescent focus inhibition test. Results The positive rate of immunity can reach 100% after being vaccinated five doses of RabV while 99.1% after being three doses. The geometric mean titers of neutralizing antibody had no significant difference between male and female cases. Young people have more quickly response to the vaccine than middle and old aged people. Conclusion To establish an acceptable standard of pre-exposure status to decide whether it is necessary to get a booster vaccination with RabV. It is necessary to detect the level of neutralizing antibody after the immunization of RabV for the people who had immune deficiency. Booster vaccination on time is recommended for the people who have negative results to garantee the effect of immunization.
出处
《中国疫苗和免疫》
CAS
2013年第4期345-348,374,共5页
Chinese Journal of Vaccines and Immunization
关键词
暴露后人群
人用狂犬病疫苗
中和抗体
快速荧光灶抑制试验
Post-exposure population
Rabies vaccine for human use
Neutralizing antibody
Rapid fluorescent focus inhibition test （RFFIT）
