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KLF5在结肠癌组织中表达的意义及与肿瘤侵袭转移的关系 被引量：3

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摘要 目的检测转录调控因子(Kr(u|¨)ppel-like factors 5,KLF5)蛋白、金属基质蛋白酶2(metalloproteincoe,MMP2)、MMP-9、基质金属蛋白酶组织抑制因子1(tissue inhibitor ofmatrixmetalloproteinase-1,TIMP-1)在结肠癌组织中的表达情况,并分析KLF5蛋白与结肠癌临床病理特征的关系。方法免疫组织化学染色检测48例结肠癌组织及30例癌旁组织中KLF5、MMP-2、MMP-9、TIMP-1的表达情况,分析其关系;记录结肠癌各项临床病理资料,分析KLF5与结肠癌临床病理特征的关系。结果结肠癌组织中KLF5、MMP-2、MMP-9表达均高于癌旁组织(P<0.05),TIMP-1在癌旁组织中表达强于原发肿瘤组织(P<0.05)。KLF5表达与肿瘤浸润深度、临床分期、淋巴结转移有关(P<0.05)。结肠癌肿瘤组织中KLF5与MMP-2、KLF5与MMP-9、MMP-2与MMP-9之间表达均存在正相关关系(r_s=0.387、0.447、0.519,P<0.05),MMP-9与TIMP-1表达存在负相关关系(r_s=-0.322,P<0.05);KLF5与TIMP-1之间、MMP-2与TIMP-1之间无明显相关关系(r_s=0.218、0.261,P>0.05)。结论结肠癌组织中KLF5蛋白表达上调,该蛋白与部分临床病理特征有关,其机制与KLF5蛋白可能调节MMP-2、MMP-9而促进肿瘤侵袭转移有关。
作者 王文韬 刘凯军 魏娉
机构地区 河北省邯郸市第一医院普通外科 冀中能源峰峰集团邯郸医院普通外科 河北省邯郸市第一医院病理科
出处 《河北医科大学学报》 CAS 2013年第10期1183-1186,共4页 Journal of Hebei Medical University
关键词 结肠肿瘤 转录因子类 肿瘤转移
分类号 R735.35 [医药卫生—肿瘤]
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参考文献12

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共引文献12

同被引文献36

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二级引证文献6

河北医科大学学报
2013年 第10期

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