摘要
目的探讨精神分裂症认知损害特点及其与血清脑源性神经营养因子(BDNF)的关系。方法对34例首发未经治疗精神分裂症患者(患者组),33名健康者(对照组)采用数字符号编码及符号搜索测验、连线测验、色字词测验、韦氏记忆测验、威斯康辛卡片分类测验和酶联免疫吸附法进行认知功能评定和血清BDNF浓度的检测。结果 (1)各项测验中,除连线A错误数[(0.58±1.15)vs(0.15±0.71),t=1.85,P=0.068]、符号搜索错误数[(2.41±3.61)vs(1.48±1.95),t=1.31,P=0.19]指标之外,患者组的成绩均差于对照组。(2)患者组血清BDNF浓度低于对照组[(2.43±1.58)μg/Lvs(3.96±2.28)μg/L,t=-3.18,P=0.002]。(3)患者组认知缺陷与血清BDNF水平之间无相关性。结论精神分裂症患者存在广泛认知损害和BDNF降低;精神分裂症认知损害与血清BDNF关系不大。
Objective To assess the relationship between cognition and brain derived neurotrophic factor （BD- NF） in patients with first-episode schizophrenia. Methods 34 patients with first-episode schizophrenia and 33 healthy controls were enrolled into the study. Their cognition ability was assessed by using a battery of neu- ropsychologieal test, which included Trail making test,, Stroop test, Symbol coding, Symbol search, Wis- consin card sorting test and Wechsler memory scale. Serum BDNF level was determined by ELISA. Results Compared with healthy controls, patients with first-episode schizophrenia had lower scores in all tests except the errors in the symbol search （（2.41±3.61） vs （1. 48±1.95）, t=1.31, P=0.19] and the errors in Trail making test A [ （0.58±1.15） vs （0.15±0.71）, t=1.85, P=0.068] .The serum BDNFlevel was lower in patients with first-episode schizophrenia than that in healthy controls [ （2.43±1.58） ug/L vs. （3.96±2.28） ug/L t=-3. 18, P=0. 002] . The impaired cognition of patients was not related to serum BDNF lev- el. Conclusions Although cognitive impairment and low BDNF level are noticed in patients with first-episode schizophrenia, the two are not closely related.
出处
《中国预防医学杂志》
CAS
2013年第10期741-744,共4页
Chinese Preventive Medicine
基金
2009年广东省自然科学基金资助项目(9151008901000027)
