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亚低温治疗新生儿缺氧缺血性脑病的研究进展 被引量:23

Research progress in mild hypothermia treatment of neonatal hypoxic-ischemic encephalopathy
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摘要 临床随机对照试验已经证实了亚低温治疗新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)的安全性和有效性,可降低病死率或严重神经系统后遗症发生率。许多发达国家的NICU已将亚低温作为治疗新生儿HIE的常规方法,我国部分NICU也逐步开展这一疗法,但接受治疗的患儿中仍有40%~50%死亡或伴有严重的神经系统发育异常。哪些病人适合接受亚低温治疗,对这些病人应采取何种降温方式、亚低温治疗的最佳时机、治疗持续的时间、最佳目标温度、亚低温联合其他治疗方法的安全性及远期预后等问题有待进一步探讨,本文将就这些问题的临床研究最新进展做一综述。 Randomized controlled trials have demonstrated the safety and efficacy of mild hypothermia in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE), which can reduce mortality or the incidence of severe neurological sequelae. Mild hypothermia has been used in the neonatal intensive care unit (NICU) as a routine treatment method for neonatal HIE in many developed countries, and it is increasingly applied in some NICUs in China. However, 40%-50% of the neonates treated with mild hypothermia die or develop severe neurological disability. Thus, to achieve the best neuroprotective effect, issues such as selection of patients with indications for mild hypothermia, cooling method, optimal time for mild hypothermia, duration of mild hypothermia, optimal target temperature, and the safety and long-term effects of mild hypothermia combined with other therapies, need to be further discussed. This article reviews the latest progress in clinical research on these issues.
作者 张鹏 程国强
出处 《中国当代儿科杂志》 CAS CSCD 北大核心 2013年第10期918-922,共5页 Chinese Journal of Contemporary Pediatrics
基金 上海市科委医学引导项目(项目编号:10411960700)
关键词 亚低温 缺氧缺血性脑病 新生儿 Mild hypothermia Hypoxic-ischemic encephalopathy Neonate
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  • 1Shankaran S, Laptook AR, Tyson JE, Ehrenkranz RA, Bann C M, Das A, et al. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy[J]. J Pediatr, 2005, 160(4): 567-572.
  • 2Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday H L, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy[J]. N Engl J Med, 2009, 361(14): 1349- 1358.
  • 3Gluekman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multieentre randomised trial[J]. Lancet, 2005, 365(9460): 663-670.
  • 4Simbruner G, Mittal RA, Rohlmann F, Muche R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo. nEURO.network RCT[J]. Pediatrics, 2010, 126(4): e771-e778.
  • 5Zhou WH, Cheng GQ, Shao XM, Liu XZ, Shan RB, Zhuang DY, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a muhicenter randomized controlled trial in China[J]. J Pediatr, 2010, 157(3): 367-372.
  • 6Jacobs SE, Morley C J, Inder TE, Stewart M J, Smith KR, McNamara PJ, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial[J]. Arch Pediatr Adolesc Med, 2011, 165(8): 692-700.
  • 7孙金峤,陈燕琳,周文浩.亚低温治疗新生儿缺氧缺血性脑病临床效果的Meta分析[J].中国循证儿科杂志,2009,4(4):340-348. 被引量:26
  • 8Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis[J]. Arch Pediatr Adolesc Med, 2012, 166(6): 558-566.
  • 9Perlman JM, Wyllie J, Kattwinkel J, Atkins DL, Chameides L, Goldsmith JP, et al. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations[J]. Circulation, 2010, 122(16 Suppl 2): $516-$538.
  • 10Perlman JM, Wyllie J, Kattwinkel J, Atkins DL, Chameides L, Goldsmith JP, et al. Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations[j], Pediatrics, 2010, 126(5): e1319-e1344.

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