摘要
目的:比较不同分期的子宫内膜异位症(EMs)合并不孕妇女采用超长GnRH-a降调节方案进行体外受精-胚胎移植(IVF-ET)助孕治疗的结局。方法:回顾性分析以超长方案降调节行IVFET助孕卵巢储备功能正常的233例EMs合并不孕患者不同EMs分期的治疗结局,按EMs分期分为A组(I^II期,102例)和B组(III^IV期,131例)。结果:①患者年龄、平均手术次数、基础FSH(bFSH)等组间无统计学差异(P>0.05)。B组有卵巢内膜异位囊肿手术史的比例明显高于A组(P<0.01)。②促性腺激素(Gn)启动日及hCG注射日性激素、Gn使用剂量及天数、获卵数、受精率、卵裂率、可移植胚胎数等组间均无统计学差异(P>0.05)。③周期取消率、临床妊娠率、种植率、流产率等组间无统计学差异(P>0.05),移植周期活产率组间相似(60.64%vs 62.18%)(P>0.05)。结论:在卵巢储备功能正常的前提下,EMs合并不孕者采用超长方案降调节实施IVF-ET助孕的结局不受EMs分期的影响。
Objective： To compare the outcome of in vitro fertilization-embryo transfer （IVF-ET） conducted with prolonged GnRH-a down-regulation protocol on infertile patients with different stages of en- dometriosis （EMs）. Methods： A retrospective analysis was performed on infertile patients with EMs regarding the IVF-ET cycles used prolonged protocol in our center. Totally, 233 patients who fulfilled all the including criteria were divided into group A （stageⅠ-Ⅱ, n=102） and group B （stage Ⅲ～Ⅳ, n=131）. The characteristics of patients, data of controlled ovarian stimulation cycles, IVF-ET outcomes of two groups were compared. Results： 1） Patients in the two groups were comparable in terms of age, surgery times and basal FSH （P〉0.05）. The proportion of patients with previous surgery of ovarian endometrioma was higher in group B than that in group A （P〈0.01）. 2） The hormone levels on gonadotropins （Gn） launch day and hCG injection day, doses and days of gonadotropins, the number of retrieved oocytes, the fertilization rate, the cleavage rate, the number of embryos transfered were comparable in two groups （P〉0.05）. 3） There was no obvious difference in the cycle cancellation rate, the clinical pregnancy rate, the implantation rate and the abortion rate between the two groups （P〉0.05）. The live birth rates of two groups were 60.64% and 62.18%, respectively （P〉0.05）. Conclusion： The outcomes of IVF-ET con- ducted with prolonged GnRH-a protocol on women with EMs-related infertility were not affected by the stages of EMs if they had normal ovarian reserve.
出处
《生殖与避孕》
CAS
CSCD
2013年第10期672-676,695,共6页
Reproduction and Contraception
基金
重庆市卫生局基金资助项目
项目编号:2011-2-303
