摘要
高危型人乳头瘤病毒(HPV)持续感染是宫颈癌发生的直接原因,然而HPV感染后多数可被宿主免疫机制清除,只在部分病例中HPV感染持续存在并与宿主细胞DNA整合,导致宿主细胞癌变。HPV表观遗传学的改变在病毒整合及致宿主细胞癌变中起一定作用。对目前有关HPV表观遗传学特点在影响HPV自身表达和宫颈病变进展中作用的文献加以综述,了解HPV DNA甲基化状态在宫颈癌发生、发展中的作用。HPV基因表观遗传学状态有可能成为临床诊断和判断预后的分子标记物。
The pathogeny of cervical cancer is persistent high-risk HPV infection. However, most of HPV infection can be cleared by the host＇s immune system, only minority will intergrate into the host＇s DNA and transform the epithelial host cells to malignant cells. Together with further genetic and epigenetic alterations of HPV play a role in virus DNA intergration and earcinogenisis. This paper reviewed how HPV epigenetic alterations can affect the expression of papillomaviral as well as the relation to the muhistep process of carcinogenesis. HPV DNA methylation level affected the carcinogenisis and progression of cervical cancer. Biomarker roles in clinical diagnosis and prognosis might be assigned to the epigenetic pattern of HPV genes.
出处
《国际妇产科学杂志》
CAS
2013年第5期443-445,共3页
Journal of International Obstetrics and Gynecology
基金
天津市卫生局科技基金(2010KY19)
关键词
宫颈肿瘤
人乳头瘤病毒16
DNA甲基化
基因沉默
Uterine cervical neoplasms
Human papiUomavirus 16
DNA methy｜ation
Gene silencing
