摘要
目的:以聚乳酸-羟基乙酸共聚物(PLGA)为材料,制备用于抗肿瘤的槲皮素-聚乳酸-羟基乙酸QC-PLGA纳米粒,并考察QC-PLGA纳米粒的体外释放机制。方法:采用乳化溶剂挥发法制备QC-PLGA纳米粒,使用透射电镜观察纳米粒的形态特征,研究QC-PLGA纳米粒的粒径、载药量、包封率、稳定性和体外释药。结果:QC-PLGA纳米粒在透射电镜观察下的形态特征为类球形实体粒子,平均粒径为(154.2±0.91)nm,载药量为(5.75±0.19)%,包封率为(43.74±1.42)%,36h体外释放84.76%,QC-PLGA冻干粉的体外释放规律基本符合Higuchi方程的释药模型。拟合的释药动力学方程为:Q=7.923 7+0.020 1t1/2(r=0.967 7)。结论:采用乳化溶剂挥发法制备的QC-PLGA纳米粒,具有明显的缓释作用,在抗肿瘤,尤其是治疗肿瘤切除术后残留癌灶方面具有广阔的应用前景。
Objective：Poly lactic acid-glycolic acid copolymer（PLGA）was prepared for anti-tumor quercetin-polylactic acid-glycolic acid QC-PLGA nanoparticles,and studied the QC-PLGA nanoparticles in vitro release mechanism.Method：Emulsion solvent evaporation method QC-PLGA nanoparticles using transmission electron microscopy the morphological characteristics of the nanoparticles and QC-PLGA nanoparticles particle size,drug loading,encapsulation efficiency,stability and in vitro release.Results：QC-PLGA nanoparticles in TEM observations morphological characteristics of particles of the spherical entity,and the average particle size（154.2 ± 0.91）nm,drug loading（5.75-± 0.19）％,encapsulation efficiency was（43.74± 1.42）％.36 hours in vitro release of 84.76％,QC-PLGA in vitro release of the freeze-dried powder law was basically in line with the release of Higuchi equation model.Release kinetics fitting equation：Q=7.923 7＋ 0.020 1t1/2（r=0.967 7）.Conclusion：Emulsion solvent evaporation method for the treatment of tumor resection of residual disease has a broad application prospect.
出处
《中医药信息》
2013年第5期62-66,共5页
Information on Traditional Chinese Medicine
基金
黑龙江中医药大学科研基金项目(201102)
