摘要
目的探讨可预测肝型肝豆状核变性(WD)患者预后的相关因素。方法收集了75例肝型WD患者的临床和实验室资料,根据他们的预后分为肝A组50例(治疗后好转)和肝B组25例(治疗后恶化放弃治疗或死亡)。比较两组临床及实验室指标的差异,采用多因素Logistic回归分析探讨相关指标与患者预后的关系。结果肝A组和肝B组之间凝血酶原时间、血清总胆红素、AST、尿酸、血清白蛋白、载脂蛋白A1(ApoA1)比较差异具有统计学意义(P均<0.05);多因素Logistic回归分析结果显示凝血酶原时间、血清总胆红素、白蛋白、ApoA1是与肝型WD患者预后相关的独立因素(P均<0.05)。结论凝血酶原时间、血清总胆红素、白蛋白、ApoA1可作为评价WD患者预后的指标。
Objective To investigate useful predictive factors relating with the prognosis of Wilson disease （WD）. Methods Clinical and laboratory data were collected from 75 consecutive paediatric WD pa- tients with liver type. They were divided respectively into two groups ： group A （ relieved after treatment） and group B （ progressive or death after treatment） according to their effect with therapy. The clinical and laboratory indicators between the two groups were compared, and multivariate logistic regression analysis was used to ex- plore the relationship between relevant indicators and prognosis. Results The levels of prothrombin time, ser- um total bilirubin, transaminase, m,ie acid, albumin and Apolipoprotein A1 （ ApoA1 ） had significant differ- ences between two groups （ P 〈 0. 05 ）. The level of prothrombin time, serum total bilirubin, Albumin and ApoA1 were independent factors to prognosis by Logistic regression analysis （ P 〈 0. 05）. Conclusions Inde- pendent indicators of poor prognosis in patients with liver hepatic degeneration included albumin, ApoAl, pro- thrombin time and serum total bilirubin.
出处
《新医学》
2013年第10期685-688,共4页
Journal of New Medicine
基金
国家自然基金(81271327)
广东省科技计划项目(2011B031800015)
关键词
肝型
肝豆状核变性
预后因素
Liver type
Wilson disease
Prognosis factors
