摘要
背景:生长因子诱导细胞向纤维软骨分化是半月板组织工程研究热点。半月板的体外构建和体内重塑与生长因子的作用关系密切。目的:概述近年来生长因子半月板组织工程研究进展,并对其机制进行探讨。方法:应用计算机检索2008年1月至2013年3月维普数据库(http://lib.cqvip.com)、中国知网数据库(www.cnki.net)及Pubmed数据库(http://www.ncbi.nlm.nih.gov/pubmed)相关文章,以"半月板组织工程;软骨;生长因子"为中文检索词;以"meniscus tissue engineering,cartilage,growth factors"为英文检索词。纳入53篇关于半月板组织工程中生长因子研究的文章。结果与结论:软骨组织工程研究中生长因子的种类繁多,新的生长因子亦在不断的被发现。生长因子对软骨调节作用的研究,从以前的单一生长因子模式开始向多生长因子间相互作用研究模式转变;生长因子对软骨调节作用的分子机制也得到了广泛的研究。生长因子在组织工程中具有良好的运用前景,但还存在着许多尚待解决的问题,如在半月板愈合过程中,不同时间阶段、不同生长因子的表达与作用均不相同,因此如何适时、适量以及怎样发挥生长因子之间的相互作用来更好的模拟体内微环境,探究生长因子对软骨调节作用的分子机制以及发现新的生长因子等都将是半月板组织工程中的研究重点。
BACKGROUND： Differentiation of growth factor-induced cells into flbrocartilage is the hot topic in the research of meniscus tissue engineering. The in vitro construction and in vivo reconstruction of rnenisd are closely related with the effect of growth factors. OBJECTIVE： To review the current development of growth factors in meniscus tissue：engineering, and to investigate the mechanism. METHODS： The VIP database （http：//lib.cqvip.com）, CNKI database （www.cntd.net） and PubMed database （http：//www.ncbi.nlm.nih.govlpubmed） were retrieved for the related articles from January 2008 to March 2013 with the key words of ＂meniscus tissue engineering, cartilage, growth factors＂. A total of 53 articles on the research of growth factors in meniscus tissue engineering were included. RESULTS AND CONCLUSION： There were various growth factors in cartilege tissue engineering research, and the new growth factors have been found in the constant. The research on the regulation effect of growth factors on cartilage was changed from the research of single growth factor modet to the research of the interactions between multiple growth factors; the molecular mechanisms of growth factors in regulating the cartilage have also been extensively studied. Growthfactors have good application prospects in tissue engineering, but there are stillmany problems to be solved, such as during the healing of menisci, the expressions and the effect of different growth factors are different in different time points. So how to play the interaction between growth factors timely and appropriately thus stimulating the in vivo microenvironment, investigating the molecular mechanisms of growth factors in regulating the cartilage, as well as finding the new growth factors are the research focus in meniscus tissue engineering.
出处
《中国组织工程研究》
CAS
CSCD
2013年第41期7303-7309,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金青年科学基金资助项目(81000798)~~
关键词
组织构建
组织构建综述
半月板
组织工程
软骨
生长因子
国家自然科学基金
menisci, tibial
cartilage
tissue engineering
transforming growth factor beta
epidermal growth factor
insulin-like growth factor I
platelet-derived growth factor
vascular endothelial growth factors
hepatocyte growth factor
fibroblast growth factors
