摘要
目的研究肺癌肿瘤抑制基因和活素在宫颈癌组织中的表达及其与临床病理各因素之间的关系。方法采用RT-PCR的实验方法检测18例宫颈癌、18例宫颈上皮内瘤变及18例正常宫颈组织中肺癌肿瘤抑制基因和活素的表达水平。结果宫颈癌组织中肺癌肿瘤抑制基因表达水平低于宫颈上皮内瘤变及正常宫颈组织,而活素表达水平高于宫颈上皮内瘤变及正常宫颈组织,在宫颈癌组织中,肺癌肿瘤抑制基因和活素的表达水平与组织学分化有关,与临床分期及病理类型无关。结论肺癌肿瘤抑制基因和活素在宫颈癌发生发展中起重要作用,且两者在宫颈癌的发展过程中起着拮抗作用。
[ Objective ] To determine expression of tunlor suppressor in lung cancer 1 （Tslcl） and Livin in human cervical malignant tumor and their relationships with clinicopathology. [Methods] The expression of Tslcl and Livin in tissues of 18 cases of cervical malignant tumor, 18 cases of CIN and 18 cases of normal cervical tissue were detected by using RT-PCR. [ Results ] The expression level of Tslc 1 in cervical malignant tumor were significantly lower than those in CIN and normal cervical tissue, the expression level of Livin in cervical malignant tumor were significantly higher than those in CIN and normal cervical tissue. The expression of Tslcl and Livin in cervical ma- lignant tumor was related to histological, without relation to clinical staging and histological grading. [ Conclusion ] The Tslcl and Livin play an important role in happening and development of cervical malignant tumor ,and Tslcl and Livin play an antergic role in development of cervical malignant tumor.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第25期37-39,共3页
China Journal of Modern Medicine
