摘要
目的筛选苦杏仁苷凝胶基质,确定制备工艺。方法采用体外经皮渗透法,使用透皮扩散试验仪,用HPLC测定接受液中苦杏仁苷含量,以透皮速率为考察指标,通过正交试验筛选基质。结果苦杏仁苷凝胶剂的优化处方组成为1%卡波姆、15%甘油、10%丙二醇、0.5%三乙醇胺。结论该凝胶制备工艺简单,透皮效果好。
OBJECTIVE To screen amygdalin gel matrix to determine the preparation process. METHODS Using transdermal diffusion test instrument in vitro, the content of amygdalin in the received solution was determined by HPLC. Steady-state penetration rate was served as investigation indexes by orthogonal test. RESULTS Matrix dosage included l%carbomer, 15% glycerin, 10%propylene glycol, 0.5% triethanolamine. CONCLUSION The preparation is simple, and the transdermal effect is good.
出处
《中国现代应用药学》
CAS
CSCD
2013年第10期1085-1088,共4页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81102686)
关键词
苦杏仁苷
凝胶
卡波姆
透皮吸收
amygdalin
gel
carbomer
percutaneous permeation
