摘要
目的:评价实施抗菌药物临床应用专项治理的效果。方法:调取某院2010年9-12月(整治前)、2011年9-12月(整治第1阶段)及2012年9-12月(整治第2阶段)的抗菌药物消耗数据,汇总分析抗菌药物消耗金额占全院药品消耗金额的比例、不同给药途径抗菌药物消耗金额及用药频度(DDDs)、各类抗菌药物DDDs、DDDs排名前15位的抗菌药物品种分布等4项指标。结果:与整治前比较,整治后上述指标改善明显。抗菌药物消耗金额占全院药品消耗金额的比例由整治前的21.67%下降至整治第1阶段的16.32%、整治第2阶段的10.16%;经注射途径给药的抗菌药物DDDs由整治前的64 190下降至整治第1阶段的50 230、整治第2阶段的35 670,降幅分别为21.75%、28.99%;经口服途径给药的抗菌药物DDDs由整治前的29 780下降至整治第1阶段的22 310、整治第2阶段的19 820,降幅分别为25.08%、11.16%;各类抗菌药物的DDDs在整治后有降也有升,其中第1代头孢菌素类抗菌药物的DDDs在整治第1阶段、第2阶段均有所上升;排名前15位抗菌药物的平均DDDs总体呈下降趋势,大部分品种的DDDs有不同程度下降。结论:实施专项整治对加强抗菌药物临床合理应用效果显著。
OBJECTIVE ： To evaluate the effects of special rectification for antibiotics use in the clinic. METHODS ： The data of antibiotics use were collected from a hospital during Sept.--Dec. in 2010 （before rectification）, Sept.--Dec. in 2011 （the first stage of rectification） and Sept.--Dec. in 2012 （the second stage of rectification）. The proportion of antibiotics cost in total drug cost, the cost and DDDs of antibiotics with different routes of administration, DDDs of various antibiotics and the distribution of top 15 antibi- otics types were all summarized and analyzed. RESULTS： Compared with before rectification, above index were all improved signif- icantly after rectification. The proportion of antibiotics cost in total drug cost decreased from 21.67% before rectification to 16.32% at the first stage of rectification and 10.16% at the second stage of rectification. DDDs of antibiotics for injection decreased from 64 190 before rectification to 50 230 at the first stage of rectification and 35 670 at the second stage of rectification, decreasing by 21.75% and 28.99%, respectively. DDDs of antibiotics with oral administration dropped from 29 780 before rectification to 22 310 at the first stage of rectification and 19 820 at the second stage of rectification, decreasing by 25.08% and 11.16%, respectively. DDDs of various antibiotics went up and down after rectification, among which that of first-generation cephalosporin antibiotics in- creased to some extent at first and second stage of rectification. The average DDDs of top 15 antibiotics was in a downtrend, and that of most types decreased to different extents. CONCLUSIONS ： The rational use of antibiotics in the clinic can be improved by special rectification significantly.
出处
《中国药房》
CAS
CSCD
2013年第42期3940-3942,共3页
China Pharmacy
基金
兰州市科技计划项目(No.2011-2-9)
关键词
抗菌药物
专项整治
消耗
Antibiotics
Special rectification
Consumption
