摘要
摘要:目的:分析3.0T磁共振DWI与UFI成像在鼻咽癌治疗中的应用价值。方法:选取2010年至2012年在本院治疗的鼻咽癌患者100例,分别进行DWI和D11检查。行DWI检查时观察患者肿瘤病灶和转移淋巴结的大小、DWI信号、ADC值的变化情况,行DTI检查时观察患者颞叶脑白质的MD值和FA值变化情况。结果:放疗后肿瘤病灶未发生明显变化前,DWI信号就已经逐渐降低,ADC值逐渐升高,放疗前后2组间相比具有统计学意义(P〈0.05)。放疗后患者颞叶白质的MD值和FA值均下降,在放疗4—6月后两者的下降最明显,而6个月后,两者的值有回升的趋势。结论:在肿瘤发生形态学改变前,DWI就能够检测病变内部微观病理改变,同时,DTI能够无创性检测放疗导致的颞叶白质的微观结构改变,联合应用DWI及DTI技术有望早期预测鼻咽癌放疗后颞叶放射性损伤。
[ Objective] To explore the clinical value of DWI and DTI imaging in the treatment of nasopharyngeal carcinoma. [Method]One hundred patients with nasopharyngeal carcinoma were randomly enrolled in this study. All patients underwent DWI and DTI examinations. Size of tumor and lymph node were evaluated base on MRI, ADC value of tumor and lymph nodes were accessed, MD and FA of white matter in temporal lobe also evaluated in this study. [Result] DWI signals post- radiation and ADC value were lower and higher than that preradiation respectively. Compared with the DTI indices pre- radiation, MD and FA value post- radiation showed decrease trend in early stage, but after radiation 6 months, the two values have a trend to recover. [ Conclusion] DWI can detect the micro- structural changes, which is early than morphological changes on T2WI. MD and FA may early detect the radiation- induced micro- structural changes of white matter in temporal lobe.
出处
《浙江医学教育》
2013年第5期45-47,50,共4页
Zhejiang Medical Education
基金
浙江省自然基金(编号Y2111306)
关键词
3
0T磁共振
鼻咽癌
扩散加权
扩散张量
3.0T magnetic resonance
nasopharyngeal carcinoma
diffusion weighted imaging
diffusion tensor