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铜绿假单胞菌重组核酸疫苗研究进展 被引量:4

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摘要 铜绿假单胞菌( Pseudomonas aeruginosa ) 为无荚膜、无芽孢、可运动的革兰阴性菌,专性需氧,广泛分布于水、土壤、空气、人和动物的皮肤和肠道中,在潮湿环境中能更好地生长。另外,医院的呼吸机、污水池、体温计、注射器和镊子等均可检出该菌。铜绿假单胞菌为条件致病菌,是医院感染的重要病原菌之一。目前铜绿假单胞菌的耐药情况日趋严重,多重耐药和广泛耐药使其临床治疗面临严峻挑战。急性铜绿假单胞菌感染若不能治愈而转为慢性后,其细菌表型会发生演变,形成生物膜,进一步降低抗菌药物的疗效。近年来,铜绿假单胞菌疫苗的研究为临床提供了新的治疗方向。传统疫苗制备工艺直接利用病原体作为免疫原,但病原体型别差异、减毒疫苗的潜在恢复感染危险和制备程序繁琐等不足限制了其大量应用。
出处 《中华传染病杂志》 CAS CSCD 北大核心 2013年第10期630-634,共5页 Chinese Journal of Infectious Diseases
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参考文献46

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