摘要
目的:建立顶空毛细管气相色谱法测定氢溴酸右荚沙芬中残留溶剂。方法:采用DB-624(30m×0.32mm,1.8μm)毛细管石英柱;程序升温;载气为氮气(N_2);FID检測器。结果:甲苯、丙酮和甲醇均能得到有效分离,各组分均有良好的线性关系(r≥0.9999);平均回收率分别为101.1%(RSD=0.67%),100.4%(RSD=0.63%),96.7%(RSD=1.2%);最低检测限分别为0.21,0.59,2.10μg·g^(-1)。结论:该方法灵敏,准确,可用于氢溴酸右美沙芬中残留溶剂的检测。
Objective ： To establish a method of headspace capillary GC for the determination of residual solvents in dextromethor- phan hydrobromide. Method ： The GC method was carried on a DB-624 （ 30 m × 0.32 mm, 1.8 μm） capillary column with program- ruing temperature control. Nitrogen was used as the carrier gas and FID was used as the detector. Result： The three residual solvents （toluene,acetone and methanol） were separated well, and the linearity was fairly good （r≥0. 999 9）. The recovery was 101.1% （RSD = 0.67% ）, 100.4% （ RSD = 0.63% ） and 96.7% （ RSD = 1. 2% ） with LOD of 0.21,0.59 and 2.10 μg · g^-1, respectively. Conclusion： The established method is sensitive and accurate, and can be used in the determination of residual solvents in dextro- methorphan hydrobromide.
出处
《中国药师》
CAS
2013年第10期1500-1502,共3页
China Pharmacist
