摘要
目的观察羟苯磺酸钙治疗脑梗死的疗效及其对血清C反应蛋白(CRP)、神经肽Y(NPY)和皮质醇动态变化的影响。方法选择2011年6月—2012年6月我科住院的脑梗死患者60例,按随机数字表法分为普通治疗组和羟苯磺酸钙治疗组,每组30例,普通治疗组行基础治疗,羟苯磺酸钙治疗组在基础治疗的基础上加用羟苯磺酸钙0.5 g/次,口服,3次/d。两组均连续治疗14 d。观察两组患者治疗前后CRP、NPY、皮质醇及美国国立卫生院脑卒中量表(NIHSS)评分的变化。结果两组患者的血清CRP、NPY水平在治疗后第7天时均高于治疗前和治疗后第14天(P<0.05),且治疗前水平高于治疗后第14天(P<0.05);皮质醇水平在治疗后第7天低于治疗前(P<0.05),治疗后第14天低于治疗后第7天(P<0.05)。组间比较显示,两组治疗后第7、14天时CRP和NPY水平间差异均有统计学意义(P<0.05),皮质醇和NIHSS评分间差异均无统计学意义(P>0.05)。脑梗死患者治疗前和治疗第7天时NIHSS评分与CRP、NPY和皮质醇水平呈正相关(P<0.05),治疗后第14天时NIHSS评分与CRP和NPY水平呈正相关(P<0.05)。结论脑梗死患者血清CRP、NPY和皮质醇水平明显增高,炎症反应、缺血和应激是病情发展的重要机制,羟苯磺酸钙治疗可以降低患者血清CRP、NPY和皮质醇的水平。
Objective To investigate dynamic changes of serum C -reactive protein （CRP）, neuropeptide Y （NPY） and cortisol and observe the clinical effects of calcium dobesilate on cerebral infarction （CI）. Methods Sixty CI pa- tients admitted to this hospital from June 2011 to June 2012 were divided randomly into groups A （given normal therapy）, B （given calcium dobesilate based on conventional therapy, 0. 5 g/time, orally, 3 times/d）. The therapies lasted 14 d. The changes of CRP, NPY, cortisol and scores of National Institutes of Health Stroke Scale （NIHSS） were observed before and after treatment. Results The levels of CRP and NPY were higher on days 7 after treatment than on days 14 after （ P 〈 0. 05 ） , higher before treatment than on days 14 after （ P 〈 0.05 ）. Cortisol level was lower on days 7 after treatment than before treatment （ P 〈 0. 05） , lower on days 14 than on days 7 after treatment （P 〈0. 05）. There was significant difference in CRP, NPY between two groups before treatment, on days 7, 14 after treatment （ P 〈 0. 05 ）, there was no in cortisol or NIHSS score （ P 〉 0. 05 ）. NIHSS scores were positively correlated with CRP, NPY, cortisol before treatment and on days 7 after （ P 〈 0.05 ）, positively with CRP, NPY on days 14 after treatment （ P 〈 0. 05 ）. Conclusion In CI patients serum levels of CRP and NPY increase sig- nificant. Inflammation, ischemia and stress are important mechanisms for the aggravation of the disease. Calcium dobesilate therapy can reduce the levels of CRP, NPY, eortisol.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第29期3441-3443,共3页
Chinese General Practice
关键词
羟苯磺酸钙
脑梗死
C反应蛋白质
神经肽Y
皮质醇
Calcium dobesilate
Brain infarction
C - reactive protein
Neuropeptide Y
Cortisol
