摘要
目的研究子痫前期孕妇尿液血管内皮生长因子(VEGF)及可溶性血管内皮生长因子受体1(sFlt-1)水平变化及其与病情程度的关系。方法采用ELISA方法检测轻度子痫前期孕妇(A组,32例)、重度子痫前期孕妇(B组,28例)、正常孕妇(C组,30例)尿液VEGF、sFlt-1水平。结果 3组孕妇尿液VEGF、sFlt-1水平比较差异均有统计学意义(均P<0.01)。C组尿液VEGF水平显著高于A、B组(P<0.01),而sFlt-1水平显著低于A、B组(P<0.01);A组尿液VEGF水平显著高于B组(P<0.01),而sFlt-1水平显著低于B组(P<0.01)。结论孕妇尿液中VEGF水平的降低、sFlt-1水平的升高与子痫前期病情程度有关,通过检测孕妇尿液VEGF、sFlt-1水平可能可以预测子痫前期的发生。
Objective To investigate the levels of vascular endothelial growth factor（VEGF） and soluble vascular endothelial growth factor receptors 1（sFlt-1）in urine and their relationship to the degree of illness in pregnant women with preeclampsia.Methods Urinary levels of VEGF and sFlt-1were measured by ELISA in 32pregnant women with mild preeclampsia（group A）,28 pregnant women with severe preeclampsia（group B）and 30normal pregnant women（group C）.Results Compared with group A,VEGF levels significantly increased in group C but decreased in group B（P＆lt;0.01）.However,sFlt-1levels significantly decreased in group C but increased in group B compared with group A（P＆lt;0.01）.Conclusion The decrease in VEGF and increased in sFlt-1in urine is associated with the degree of preeclampsia.Maternal urine VEGF and sFlt-1can be used as predictive markers of preeclampsia.
出处
《南昌大学学报（医学版）》
CAS
2013年第8期42-43,103,共3页
Journal of Nanchang University：Medical Sciences
关键词
子痫前期
血管内皮生长因子
可溶性血管内皮生长因子受体1
孕妇
preeclampsia
vascular endothelial growth factor
soluble vascular endothelial growth factor receptors 1
pregnant women
