摘要
Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a treatment group （59 cases） and a control group （58 cases）. The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO. Results Compared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group （P〈0.05）. After the treatment, the migraine scores were both significantly decreased in two groups （P〈0.05, P〈0.01）, which was more obvious in the treatment group （P〈0.05）. The level of ET and NO was significantly changed after treatment （P〈0.05, P〈0.01）. Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group （both P〈0.05）. Conclusion The Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.
目的:观察赤凤迎源针法治疗偏头痛的临床疗效及对血浆内皮素(ET)、一氧化氮(NO)的影响。方法:将117例患者随机分为治疗组(59例)和对照组(58例)。治疗组采用赤凤迎源针法治疗;对照组采用口服盐酸氟桂利嗪胶囊治疗,连续治疗4周。对比两组患者临床疗效及治疗前后头痛积分;用放射免疫法测定两组患者治疗前后血浆ET水平,用硝酸还原酶法测定两组患者治疗前后血浆NO水平。结果:两组患者疗效比较,治疗组总有效率为91.5%,对照组总有效率为70.7%,治疗组优于对照组(P<0.05)。两组患者治疗后头痛积分均明显降低(P<0.05,P<0.01),治疗组较对照组头痛积分下降更为明显(P<0.05)。治疗组及对照组治疗后ET、NO水平均有很明显变化(P<0.01,P<0.05);两组治疗后比较,治疗组ET、NO水平改善优于对照组(均P<0.05)。结论:赤凤迎源针法治疗偏头痛疗效确切、安全,无不良反应,其取效的机制可能是较好地调节血浆ET、NO水平,维持脑血管正常的舒缩功能。
