摘要
脓毒症（sepsis）是由感染引起的全身炎症反应综合征（SIRS）,可进展为重度脓毒症、脓毒性休克和多器官功能障碍综合征（MODS）,其发病率高、病死率高,已成为ICU患者的首位死亡因素.据统计,近三十年脓毒症的发病率以每年1.5%的比例上升,病死率平均高达40%,因此其早期诊断与治疗至关重要.可溶性髓样细胞触发受体-1 （soluble triggering receptor expressed on myeloid cells-1,sTREM-1）是近年发现的一种新型炎症激发受体,其激活后可通过炎症信号通路引起机体炎症反应并级联放大,在基础和临床研究中逐渐受到关注.目前多项研究发现,sTREM-1在脓毒症、肺炎、脑膜炎、重症急性胰腺炎及炎症性肠病等诊断、感染严重程度的判断方面有重要的意义.因此有必要对目前sTREM-1与脓毒症关系的研究进展做一综述,以期为研究人员及临床医师对脓毒症的认识及治疗等提供指导意义.
Sepsis is a systemic inflammatory response syndrome caused by infection, which can progress into severe sepsis, septic shock and multiple organ dysfunction syndrome. Because of its high incidence and high mortality, sepsis has become the first cause of death of ICU patients. In the recent three decades, the incidence of sepsis rises by 1.5% every year, and the average mortality rate is as high as 40%. Thus, it is completely crucial for early diagnosis and therapy. Soluble triggering receptor expressed on myeloid cells - 1 （ sTREM - 1 ） is a new type of inflammation stimulating receptor which has been found recently, and its activation by inflammatory signal pathway results in inflammatory cascade reaction. Many researchers suggest that sTREM - 1 plays an important role in the diagnosis and evaluation of infection severity of sepsis, pneumonia, meningitis, severe acute pancreatitis and inflammatory bowel disease. Therefore, it is necessary to review the development of the relationship between sTREM - 1 and sepsis in order to provide guidance for researchers and clinicians to understand and treat sepsis.
出处
《中国急救医学》
CAS
CSCD
北大核心
2013年第10期951-954,共4页
Chinese Journal of Critical Care Medicine
