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鼻咽癌后程三维适形放疗疗效分析

Curative analysis of late-course 3-dimensional conformal radiotherapy for nasopharyngeal carcinoma
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摘要 目的评价后程三维适形放疗(3DCRT)治疗鼻咽癌(NPC)的近期和远期疗效。方法收集179例NPC患者,其中Ⅰ、Ⅱ、Ⅲ、Ⅳa期分别为16、49、61、53例。所有患者鼻咽和上颈部靶区均采用前程常规放疗联合后程3DCRT,放疗处方剂量为70 Gy/35次,每天1次,每周5次,其中常规放疗36 Gy/18次,3DCRT 34 Gy/17次。结果 179例患者随访率为98.3%(176/179)。全组患者5年局部控制率、无远处转移生存率、无瘤生存率和总生存率分别为75.0%(132/176)、57.4%(101/176)、47.7%(84/176)和62.5%(110/176)。不良反应以Ⅰ、Ⅱ级为主,其发生率与Ⅲ、Ⅳ级不良反应发生率比较,差异均有统计学意义(P<0.01)。结论前程常规放疗联合同期后程3DCRT用于NPC治疗获得了较好的远期疗效和生存质量。 Objective To evaluate the curative efficacy in short-term and long-term of late-course 3-dimensional conforreal radiotherapy(3DCRT) for nasopharyngeal carcinoma(NPC). Methods A total of 179 patients with NPC were collected, including 16 cases with Grade I ,49 cases with Grade II , 61 cases with Grade III and 53 cases with Grade IVa respectively. Early course routine radiotherapy combined with concurrent late course 3DCRT method was used to nasopharyngeal and target area of the neck. The prescription dose of radiotherapy was 70Gy/35 times, once daily, five times per week, with 36Gy/18 times of routine radiotherapy and 34Gy/17 times of 3DCRT. Results The follow-up rate of 179 patients was 98.6% (176/179). The 5-year local control rate, free from distant metastasis survival rate, disease free survival and overall survival rate in all the patients was 75.0% (132/176) ,57.4%(101/176) ,47.7%(84/176) and 62.5%(110/176) respectively. The adverse reactions were mainly in Grade I and Grade II,comparing with the incidence rate of the incidence rated of Grade III and Grade IV ,the difference had statistical significance (P〈0.01). Conclusion Early course routine radiotherapy combined with concurrent late course 3DCRT for NPC can obtain better long-term efficacy and high quality of life.
出处 《现代医药卫生》 2013年第19期2894-2895,2897,共3页 Journal of Modern Medicine & Health
关键词 鼻咽肿瘤 放射疗法 适形 存活率 预后 后程三维适形 Nasopharyngeal neoplasms Radiotherapy, eonformal Survival rate Prognosis Late course 3- dimensional conformal radiation therapy
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  • 1贺蓓娃,邹勤舟,张福正,赵于天,赵涤非.鼻咽癌放射治疗后肿瘤残留与疗效的临床分析[J].中华放射肿瘤学杂志,2004,13(3):150-152. 被引量:16
  • 2孔琳,张有望,吴永如,郭小毛,李龙根.鼻咽癌放射治疗后颅神经损伤影响因素研究[J].中华放射肿瘤学杂志,2005,14(1):10-14. 被引量:16
  • 3肖建平,徐国镇,高黎,秦德兴,蔡伟民,李素艳.鼻咽癌初程放疗后残存的分次X刀治疗初探[J].中华放射肿瘤学杂志,2005,14(2):77-80. 被引量:24
  • 4叶元胜,詹仁雅,童鹰.Cyclin D_1在颅脑胶质瘤中表达及细胞周期表达模式的研究[J].浙江临床医学,2005,7(9):899-900. 被引量:6
  • 5Lee AWM,Poon YF,Foo W, et al. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985 : overall survival and patterns of failure. Int J Radiat Oneol Biol Phys, 1992,23 : 261-270.
  • 6Zhang EP,Lian PG, Cai Kl,,et al. Radiation therapy of nasopharyngeal carcinoma: prognostic factors based on a 10-year follow-up of 1302 patients, lnt J Radiat Oncol Biol Phys, 1989,16: 301- 305.
  • 7Emami B,Sethi A,Petruzzelli CJ. Influence of MRI on target volume delineation and IMRT planning in nasopharyngeal carcinoma. Int J Radiat Oncol Blot Phys,2003,57: 481-488.
  • 8Chung NN,Ting LL,Hsu WC,et al. Impact of magnetic resonance imaging versus CT on nasopharyngeal carcinoma: primary tumor target delineation for radiotherapy. Head Neck, 2004,26 : 241 - 246.
  • 9Yeh SA,Tang Y, Lui CC ,et al. Treatment outcomes and Late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone, Int J Radiat Oneol Biol Phys,2005,62: 672-679.
  • 10Leung TW,Tung SY,Sze WK,et al. Treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. Head Neck,2005,27 : 555-565.

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