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序贯疗法治疗幽门螺杆菌阳性胃溃疡疗效观察 被引量:14

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摘要 目的探讨序贯疗法治疗幽门螺杆菌(Hp)阳性胃溃疡的疗效与安全性。方法 273例Hp阳性胃溃疡患者随机分为两组:治疗组137例采用序贯疗法(雷贝拉唑20 mg bid,阿莫西林0.5 g bid,连续5 d;继服雷贝拉唑20 mg bid,克拉霉素0.5 mg bid,替硝唑0.5 mg bid,连续5 d),共治疗10 d。对照组136例予三联疗法(雷贝拉唑20 mg bid,阿莫仙胶囊0.5 g bid,克拉霉素0.5 mg bid),连续治疗10 d。两组上述治疗完成后均续服雷贝拉唑20 mg qd,连续4周。停药4周后观察两组Hp根除率、溃疡愈合率和不良反应。结果观察组Hp根除率(91.97%)和溃疡愈合率(88.32%)明显高于对照组Hp根除率(82.35%)和溃疡愈合率(71.32%)(P均<0.01);观察组不良反应发生率(8.03%)明显低于对照组(19.12%)(P<0.01)。结论序贯疗法治疗Hp阳性胃溃疡,疗效好,溃疡愈合率高,可降低不良反应发生率。
作者 郭云霞
出处 《中国临床研究》 CAS 2013年第10期1033-1034,共2页 Chinese Journal of Clinical Research
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