摘要
香豆素(coumarins)是具有苯骈α-吡喃酮结构的一类化合物,具有抗肿瘤、抗凝血、抗艾滋病毒、抗炎、抗氧化、抗菌等多种药理活性。近年来研究者发现众多结构特异的香豆素类化合物具有显著的抗肿瘤活性,并报道了其对肿瘤细胞代谢和信号转导通路的影响,充分证明了香豆素类化合物在抗癌药物研发中的重要性。本文以香豆素的基本结构进行分类,综述了天然和合成的香豆素类化合物在抗肿瘤药物方面的研究进展。
Coumarins are a group of compounds with an α-benzopyrone structure, and have shown antitumor, anti-coagulation, anti-HIV, anti-inflammatory, anti-oxidation, anti-bacterial and other pharmacological activities. In recent years, the researchers have isolated or synthesized many structurally specific coumarin derivatives with excellent anti-tumor activity and explored the influence of coumarins on enzymes and cell pathways related to the metabolism of tumor cells, which proves adequately the importance of coumarin skeleton in the research and development of anticancer drugs. In this paper, we reviewed the application of many natural and synthetic coumarins which are classified by classical coumarin structures on exploring new anticancer drugs.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第20期2392-2404,共13页
Chinese Journal of New Drugs
关键词
香豆素
抗肿瘤
研究进展
coumarins
anti-tumor
research advance
